OCA at 06:01, 2 March 2023

OCA — Thu, 02 Mar 2023 06:01:11 GMT

←Older revision		Revision as of 06:01, 2 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8aqu is ~~ON HOLD~~	+	==BA.1 SARS-CoV-2 Spike bound to mouse ACE2 (local)==
-		+	<StructureSection load='8aqu' size='340' side='right'caption='[[8aqu]], [[Resolution\|resolution]] 3.22Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8aqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqu OCA], [https://pdbe.org/8aqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqu RCSB], [https://www.ebi.ac.uk/pdbsum/8aqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GCAM_MOUSE GCAM_MOUSE] [https://www.uniprot.org/uniprot/ACE2_MOUSE ACE2_MOUSE] Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:12075344, PubMed:12967627). By cleavage of angiotensin II, may also have a protective role in acute lung injury (PubMed:16001071). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:19185582, PubMed:18424768, PubMed:22677001).[UniProtKB:Q9BYF1]<ref>PMID:12075344</ref> <ref>PMID:12967627</ref> <ref>PMID:16001071</ref> <ref>PMID:18424768</ref> <ref>PMID:19185582</ref> <ref>PMID:22677001</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Alexander M]]
		+	[[Category: Bertrand B]]
		+	[[Category: Dong CN]]
		+	[[Category: Emiko U]]
		+	[[Category: Florence P]]
		+	[[Category: Henning S]]
		+	[[Category: Kelvin L]]
		+	[[Category: Sergey N]]

OCA at 09:04, 1 February 2023

OCA — Wed, 01 Feb 2023 09:04:23 GMT

←Older revision		Revision as of 09:04, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8aqu is ON HOLD ~~until Paper Publication~~	+	The entry 8aqu is ON HOLD

	Authors:		Authors:

OCA at 05:36, 14 September 2022

OCA — Wed, 14 Sep 2022 05:36:45 GMT

←Older revision		Revision as of 05:36, 14 September 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8aqu is ON HOLD	+	The entry 8aqu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8aqu" [edit=sysop:move=sysop]

OCA — Thu, 25 Aug 2022 03:44:13 GMT

Protected "8aqu" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:44, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 8aqu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 25 Aug 2022 03:44:12 GMT

New page: '''Unreleased structure''' The entry 8aqu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8aqu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8aqu - Revision history

OCA at 06:01, 2 March 2023

OCA at 09:04, 1 February 2023

OCA at 05:36, 14 September 2022

OCA: Protected "8aqu" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8aqu is ON HOLD Authors: Description: Category: Unreleased Structures