OCA at 09:51, 15 March 2023

OCA — Wed, 15 Mar 2023 09:51:11 GMT

←Older revision		Revision as of 09:51, 15 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8aqw is ~~ON HOLD~~	+	==BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)==
-		+	<StructureSection load='8aqw' size='340' side='right'caption='[[8aqw]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8aqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AQW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8aqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8aqw OCA], [https://pdbe.org/8aqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8aqw RCSB], [https://www.ebi.ac.uk/pdbsum/8aqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8aqw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/WAC_BPT4 WAC_BPT4] Chaperone responsible for attachment of long tail fibers to virus particle. Forms the fibrous structure on the neck of the virion called whiskers. During phage assembly, 6 fibritin molecules attach to each virion neck through their N-terminal domains, to form a collar with six fibers ('whiskers').[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia virus T4]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Beckert B]]
		+	[[Category: Lau K]]
		+	[[Category: Myasnikov A]]
		+	[[Category: Nazarov S]]
		+	[[Category: Ni D]]
		+	[[Category: Pojer F]]
		+	[[Category: Stahlberg H]]
		+	[[Category: Uchikawa E]]

OCA at 09:04, 1 February 2023

OCA — Wed, 01 Feb 2023 09:04:28 GMT

←Older revision		Revision as of 09:04, 1 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8aqw is ON HOLD ~~until Paper Publication~~	+	The entry 8aqw is ON HOLD

	Authors:		Authors:

OCA at 05:36, 14 September 2022

OCA — Wed, 14 Sep 2022 05:36:49 GMT

←Older revision		Revision as of 05:36, 14 September 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8aqw is ON HOLD	+	The entry 8aqw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8aqw" [edit=sysop:move=sysop]

OCA — Thu, 25 Aug 2022 03:44:17 GMT

Protected "8aqw" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:44, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 8aqw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 25 Aug 2022 03:44:16 GMT

New page: '''Unreleased structure''' The entry 8aqw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8aqw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8aqw - Revision history

OCA at 09:51, 15 March 2023

OCA at 09:04, 1 February 2023

OCA at 05:36, 14 September 2022

OCA: Protected "8aqw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8aqw is ON HOLD Authors: Description: Category: Unreleased Structures