8atk - Revision history

OCA at 05:52, 5 July 2023

OCA — Wed, 05 Jul 2023 05:52:34 GMT

←Older revision		Revision as of 05:52, 5 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8atk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ATK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ATK FirstGlance]. <br>		<table><tr><td colspan='2'>[[8atk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ATK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ATK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8atk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8atk OCA], [https://pdbe.org/8atk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8atk RCSB], [https://www.ebi.ac.uk/pdbsum/8atk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8atk ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8atk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8atk OCA], [https://pdbe.org/8atk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8atk RCSB], [https://www.ebi.ac.uk/pdbsum/8atk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8atk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:00, 25 May 2023

OCA — Thu, 25 May 2023 04:00:55 GMT

←Older revision		Revision as of 04:00, 25 May 2023
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-	'''Unreleased structure'''

-	The ~~entry~~ 8atk ~~is ON HOLD until Paper Publication~~	+	==The SH2 domain of mouse SH2B1==
-		+	<StructureSection load='8atk' size='340' side='right'caption='[[8atk]]' scene=''>
-	~~Authors~~: ~~Fowler~~, N.J., ~~Williamson~~, M.P., ~~Albalwi~~, M.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8atk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ATK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ATK FirstGlance]. <br>
-	~~Description~~: ~~The SH2 domain~~ of ~~mouse~~ SH2B1	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8atk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8atk OCA], [https://pdbe.org/8atk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8atk RCSB], [https://www.ebi.ac.uk/pdbsum/8atk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8atk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Albalwi, M.F~~]]	+	== Function ==
-	[[Category: ~~Williamson, M.P~~]]	+	[https://www.uniprot.org/uniprot/SH2B1_MOUSE SH2B1_MOUSE] Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity (By similarity). Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis, according the order: isoform 3 > isoform 4 > isoform 1 > isoform 2.<ref>PMID:11502739</ref> <ref>PMID:15316008</ref> <ref>PMID:16098827</ref> <ref>PMID:9343427</ref>
-	[[Category: Fowler~~, N.J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Albalwi MF]]
		+	[[Category: Fowler NJ]]
		+	[[Category: Williamson MP]]

OCA at 04:42, 9 November 2022

OCA — Wed, 09 Nov 2022 04:42:10 GMT

←Older revision		Revision as of 04:42, 9 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8atk is ON HOLD	+	The entry 8atk is ON HOLD until Paper Publication

	Authors: Fowler, N.J., Williamson, M.P., Albalwi, M.F.		Authors: Fowler, N.J., Williamson, M.P., Albalwi, M.F.
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	Description: The SH2 domain of mouse SH2B1		Description: The SH2 domain of mouse SH2B1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Albalwi, M.F]]
	[[Category: Williamson, M.P]]		[[Category: Williamson, M.P]]
	[[Category: Fowler, N.J]]		[[Category: Fowler, N.J]]
-	[[Category: Albalwi, M.F]]

OCA: Protected "8atk" [edit=sysop:move=sysop]

OCA — Wed, 31 Aug 2022 05:27:58 GMT

Protected "8atk" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 31 August 2022

OCA: New page: '''Unreleased structure''' The entry 8atk is ON HOLD Authors: Fowler, N.J., Williamson, M.P., Albalwi, M.F. Description: The SH2 domain of mouse SH2B1 [[Category: Unreleased Structures...

OCA — Wed, 31 Aug 2022 05:27:57 GMT

New page: '''Unreleased structure''' The entry 8atk is ON HOLD Authors: Fowler, N.J., Williamson, M.P., Albalwi, M.F. Description: The SH2 domain of mouse SH2B1 [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 8atk is ON HOLD

Authors: Fowler, N.J., Williamson, M.P., Albalwi, M.F.

Description: The SH2 domain of mouse SH2B1
[[Category: Unreleased Structures]]
[[Category: Williamson, M.P]]
[[Category: Fowler, N.J]]
[[Category: Albalwi, M.F]]