OCA at 10:26, 15 February 2023

OCA — Wed, 15 Feb 2023 10:26:16 GMT

←Older revision		Revision as of 10:26, 15 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8auk is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of human BIRC6 in complex with HTRA2==
-		+	<StructureSection load='8auk' size='340' side='right'caption='[[8auk]], [[Resolution\|resolution]] 6.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8auk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AUK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8auk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8auk OCA], [https://pdbe.org/8auk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8auk RCSB], [https://www.ebi.ac.uk/pdbsum/8auk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8auk ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BIRC6_HUMAN BIRC6_HUMAN] Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.<ref>PMID:14765125</ref> <ref>PMID:15200957</ref> <ref>PMID:18329369</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Clausen T]]
		+	[[Category: Ehrmann JF]]
		+	[[Category: Grabarczyk DB]]

OCA at 03:47, 26 October 2022

OCA — Wed, 26 Oct 2022 03:47:10 GMT

←Older revision		Revision as of 03:47, 26 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8auk is ON HOLD	+	The entry 8auk is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8auk" [edit=sysop:move=sysop]

OCA — Wed, 31 Aug 2022 05:29:28 GMT

Protected "8auk" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 31 August 2022

OCA: New page: '''Unreleased structure''' The entry 8auk is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 Aug 2022 05:29:27 GMT

New page: '''Unreleased structure''' The entry 8auk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8auk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8auk - Revision history

OCA at 10:26, 15 February 2023

OCA at 03:47, 26 October 2022

OCA: Protected "8auk" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8auk is ON HOLD Authors: Description: Category: Unreleased Structures