OCA at 11:10, 14 March 2024

OCA — Thu, 14 Mar 2024 11:10:51 GMT

←Older revision		Revision as of 11:10, 14 March 2024
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-	'''Unreleased structure'''

-	The ~~entry~~ 8axw is ~~ON HOLD~~	+	==The structure of mouse AsterC (GramD1c) with Ezetimibe==
-		+	<StructureSection load='8axw' size='340' side='right'caption='[[8axw]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8axw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AXW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H56:(3~{R},4~{S})-1-(4-fluorophenyl)-3-[(3~{S})-3-(4-fluorophenyl)-3-oxidanyl-propyl]-4-(4-hydroxyphenyl)azetidin-2-one'>H56</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8axw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8axw OCA], [https://pdbe.org/8axw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8axw RCSB], [https://www.ebi.ac.uk/pdbsum/8axw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8axw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ASTRC_MOUSE ASTRC_MOUSE] Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (PubMed:30220461). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (PubMed:30220461). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (PubMed:30220461). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (PubMed:30220461). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (PubMed:30220461).<ref>PMID:30220461</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Burger L]]
		+	[[Category: Fairall L]]
		+	[[Category: Schwabe JWR]]
		+	[[Category: Tontonoz P]]
		+	[[Category: Xiao X]]

OCA: Protected "8axw" [edit=sysop:move=sysop]

OCA — Wed, 07 Sep 2022 15:28:36 GMT

Protected "8axw" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:28, 7 September 2022

OCA: New page: '''Unreleased structure''' The entry 8axw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Sep 2022 15:28:35 GMT

New page: '''Unreleased structure''' The entry 8axw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8axw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8axw - Revision history

OCA at 11:10, 14 March 2024

OCA: Protected "8axw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8axw is ON HOLD Authors: Description: Category: Unreleased Structures