OCA at 10:14, 24 November 2022

OCA — Thu, 24 Nov 2022 10:14:32 GMT

←Older revision		Revision as of 10:14, 24 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8b8d is ~~ON HOLD until Paper~~ Publication	+	==multimerization domain of Gaboon Viper Virus 1==
		+	<StructureSection load='8b8d' size='340' side='right'caption='[[8b8d]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8b8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Gaboon_viper_virus_1 Gaboon viper virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8D FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8d OCA], [https://pdbe.org/8b8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8d RCSB], [https://www.ebi.ac.uk/pdbsum/8b8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8d ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/L0N429_9MONO L0N429_9MONO]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Determining the structural organisation of viral replication complexes and unravelling the impact of infection on cellular homeostasis represent important challenges in virology. This may prove particularly useful when confronted with viruses that pose a significant threat to human health, that appear unique within their family, or for which knowledge is scarce. Among Mononegavirales, bornaviruses (family Bornaviridae) stand out due to their compact genomes and their nuclear localisation for replication. The recent recognition of the zoonotic potential of several orthobornaviruses has sparked a surge of interest in improving our knowledge on this viral family. In this work, we provide a complete analysis of the structural organisation of Borna disease virus 1 (BoDV-1) phosphoprotein (P), an important cofactor for polymerase activity. Using X-ray diffusion and diffraction experiments, we revealed that BoDV-1 P adopts a long coiled-coil alpha-helical structure split into two parts by an original beta-strand twist motif, which is highly conserved across the members of whole Orthobornavirus genus and may regulate viral replication. In parallel, we used BioID to determine the proximal interactome of P in living cells. We confirmed previously known interactors and identified novel proteins linked to several biological processes such as DNA repair or mRNA metabolism. Altogether, our study provides important structure/function cues, which may improve our understanding of BoDV-1 pathogenesis.

-	~~Authors: Tarbouriech~~, N., ~~Legrand~~, P., ~~Bouhris~~, ~~J.M.~~, ~~Horie~~, M., Tomonaga, K., ~~Crepin~~, T.	+	Borna Disease Virus 1 Phosphoprotein Forms a Tetramer and Interacts with Host Factors Involved in DNA Double-Strand Break Repair and mRNA Processing.,Tarbouriech N, Chenavier F, Kawasaki J, Bachiri K, Bourhis JM, Legrand P, Freslon LL, Laurent EMN, Suberbielle E, Ruigrok RWH, Tomonaga K, Gonzalez-Dunia D, Horie M, Coyaud E, Crepin T Viruses. 2022 Oct 26;14(11):2358. doi: 10.3390/v14112358. PMID:36366462<ref>PMID:36366462</ref>

-	~~Description: multimerization domain~~ of ~~Gaboon Viper Virus 1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Legrand, P~~]]	+	<div class="pdbe-citations 8b8d" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Tarbouriech, N~~]]	+	== References ==
-	[[Category: Crepin, T]]	+	<references/>
-	[[Category: ~~Bouhris, J.~~M]]	+	__TOC__
-	[[Category: ~~Tomonaga, K~~]]	+	</StructureSection>
-	[[Category: ~~Horie, M~~]]	+	[[Category: Gaboon viper virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Bouhris JM]]
		+	[[Category: Crepin T]]
		+	[[Category: Horie M]]
		+	[[Category: Legrand P]]
		+	[[Category: Tarbouriech N]]
		+	[[Category: Tomonaga K]]

OCA: Protected "8b8d" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 16:52:51 GMT

Protected "8b8d" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:52, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8b8d is ON HOLD until Paper Publication Authors: Tarbouriech, N., Legrand, P., Bouhris, J.M., Horie, M., Tomonaga, K., Crepin, T. Description: mult...

OCA — Wed, 19 Oct 2022 16:52:49 GMT

New page: '''Unreleased structure''' The entry 8b8d is ON HOLD until Paper Publication Authors: Tarbouriech, N., Legrand, P., Bouhris, J.M., Horie, M., Tomonaga, K., Crepin, T. Description: mult...

New page

'''Unreleased structure'''

The entry 8b8d is ON HOLD until Paper Publication

Authors: Tarbouriech, N., Legrand, P., Bouhris, J.M., Horie, M., Tomonaga, K., Crepin, T.

Description: multimerization domain of Gaboon Viper Virus 1
[[Category: Unreleased Structures]]
[[Category: Legrand, P]]
[[Category: Tarbouriech, N]]
[[Category: Crepin, T]]
[[Category: Bouhris, J.M]]
[[Category: Tomonaga, K]]
[[Category: Horie, M]]

8b8d - Revision history

OCA at 10:14, 24 November 2022

OCA: Protected "8b8d" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8b8d is ON HOLD until Paper Publication Authors: Tarbouriech, N., Legrand, P., Bouhris, J.M., Horie, M., Tomonaga, K., Crepin, T. Description: mult...