8b8z - Revision history

OCA at 07:57, 1 May 2024

OCA — Wed, 01 May 2024 07:57:25 GMT

←Older revision		Revision as of 07:57, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8b8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[8b8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q33:4,5-bis(chloranyl)-~{N}3-phenyl-~{N}1-(phenylmethyl)benzene-1,3-dicarboxamide'>Q33</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q33:4,5-bis(chloranyl)-~{N}3-phenyl-~{N}1-(phenylmethyl)benzene-1,3-dicarboxamide'>Q33</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8z OCA], [https://pdbe.org/8b8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8z RCSB], [https://www.ebi.ac.uk/pdbsum/8b8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8z OCA], [https://pdbe.org/8b8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8z RCSB], [https://www.ebi.ac.uk/pdbsum/8b8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8z ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>		[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+
		+	==See Also==
		+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:06, 28 December 2022

OCA — Wed, 28 Dec 2022 09:06:30 GMT

←Older revision		Revision as of 09:06, 28 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8b8z is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal structure of mutant PPARG (C313A) and NCOR2 with an inverse agonist (compound 7e)==
-		+	<StructureSection load='8b8z' size='340' side='right'caption='[[8b8z]], [[Resolution\|resolution]] 2.22Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8b8z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B8Z FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Q33:4,5-bis(chloranyl)-~{N}3-phenyl-~{N}1-(phenylmethyl)benzene-1,3-dicarboxamide'>Q33</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b8z OCA], [https://pdbe.org/8b8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b8z RCSB], [https://www.ebi.ac.uk/pdbsum/8b8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b8z ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Friberg A]]
		+	[[Category: Goldstein J]]
		+	[[Category: Lemke CT]]
		+	[[Category: Orsi DL]]
		+	[[Category: Pook E]]
		+	[[Category: Puetter V]]
		+	[[Category: Siegel S]]
		+	[[Category: Stellfeld T]]

OCA at 04:46, 9 November 2022

OCA — Wed, 09 Nov 2022 04:46:58 GMT

←Older revision		Revision as of 04:46, 9 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8b8z is ON HOLD	+	The entry 8b8z is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8b8z" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 16:55:50 GMT

Protected "8b8z" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:55, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8b8z is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Oct 2022 16:55:48 GMT

New page: '''Unreleased structure''' The entry 8b8z is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8b8z is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]