8bah - Revision history

OCA at 16:11, 13 December 2023

OCA — Wed, 13 Dec 2023 16:11:05 GMT

←Older revision		Revision as of 16:11, 13 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bah]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bah]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bah OCA], [https://pdbe.org/8bah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bah RCSB], [https://www.ebi.ac.uk/pdbsum/8bah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bah OCA], [https://pdbe.org/8bah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bah RCSB], [https://www.ebi.ac.uk/pdbsum/8bah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bah ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:38, 11 January 2023

OCA — Wed, 11 Jan 2023 07:38:52 GMT

←Older revision		Revision as of 07:38, 11 January 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8bah is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human Mre11-Nbs1 complex==
		+	<StructureSection load='8bah' size='340' side='right'caption='[[8bah]], [[Resolution\|resolution]] 4.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8bah]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BAH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bah OCA], [https://pdbe.org/8bah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bah RCSB], [https://www.ebi.ac.uk/pdbsum/8bah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bah ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/MRE11_HUMAN MRE11_HUMAN] Hereditary breast and ovarian cancer syndrome;Ataxia-telangiectasia-like disorder. The disease is caused by mutations affecting the gene represented in this entry. Defects in MRE11A can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. A homozygous truncating mutation MRE11A has been found in patients with cerebellar vermis hypoplasia, ataxia and dysarthria.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MRE11_HUMAN MRE11_HUMAN] Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break sites. How MRN can act both as nuclease and scaffold protein is not well understood. The cryo-EM structure of MRN from Chaetomium thermophilum reveals a 2:2:1 complex with a single Nbs1 wrapping around the autoinhibited Mre11 nuclease dimer. MRN has two DNA-binding modes, one ATP-dependent mode for loading onto DNA ends and one ATP-independent mode through Mre11's C terminus, suggesting how it may interact with DSBs and intact DNA. MRNs two 60-nm-long coiled-coil domains form a linear rod structure, the apex of which is assembled by the two joined zinc-hook motifs. Apices from two MRN complexes can further dimerize, forming 120-nm spanning MRN-MRN structures. Our results illustrate the architecture of MRN and suggest how it mechanistically integrates catalytic and tethering functions.

-	~~Authors~~:	+	Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.,Rotheneder M, Stakyte K, van de Logt E, Bartho JD, Lammens K, Fan Y, Alt A, Kessler B, Jung C, Roos WP, Steigenberger B, Hopfner KP Mol Cell. 2022 Dec 20:S1097-2765(22)01138-8. doi: 10.1016/j.molcel.2022.12.003. PMID:36577401<ref>PMID:36577401</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8bah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Bartho JD]]
		+	[[Category: Hopfner KP]]
		+	[[Category: Lammens K]]
		+	[[Category: Rotheneder M]]
		+	[[Category: Stakyte K]]

OCA at 07:46, 24 November 2022

OCA — Thu, 24 Nov 2022 07:46:42 GMT

←Older revision		Revision as of 07:46, 24 November 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bah is ON HOLD	+	The entry 8bah is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8bah" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 17:00:53 GMT

Protected "8bah" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:00, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8bah is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Oct 2022 17:00:50 GMT

New page: '''Unreleased structure''' The entry 8bah is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bah is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]