OCA at 07:28, 18 January 2023

OCA — Wed, 18 Jan 2023 07:28:22 GMT

←Older revision		Revision as of 07:28, 18 January 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8bg9 ~~is ON HOLD~~	+	==Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains \| ABeta==
-		+	<StructureSection load='8bg9' size='340' side='right'caption='[[8bg9]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~Authors~~: ~~Yang, Y~~.~~, Zhang, W~~.J.~~, Murzin, A~~.G., ~~Schweighauser, M~~., ~~Huang, M~~., ~~Lovestam~~, S.K.A., ~~Peak~~-~~Chew, S~~.Y.~~, Macdonald, J~~., ~~Lavenir, I~~.~~, Ghetti, B~~.~~, Graff, C~~.~~, Kumar, A~~.~~, Nordber, A~~., ~~Goedert, M~~.~~, Scheres, S~~.H.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bg9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BG9 FirstGlance]. <br>
-	~~Description: Murine~~ amyloid-beta ~~filaments~~ with the ~~Arctic mutation~~ (~~E22G~~) ~~from~~ APP(NL-G-F) ~~mouse brains \| ABeta~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bg9 OCA], [https://pdbe.org/8bg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bg9 RCSB], [https://www.ebi.ac.uk/pdbsum/8bg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bg9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Ghetti, B]]	+	== Function ==
-	[[Category: ~~Peak-Chew, S.Y~~]]	+	[https://www.uniprot.org/uniprot/A4_MOUSE A4_MOUSE] Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons (By similarity). Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.<ref>PMID:15677459</ref> Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also bind GPC1 in lipid rafts (By similarity).<ref>PMID:15677459</ref> The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.<ref>PMID:15677459</ref> N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (By similarity).<ref>PMID:15677459</ref>
-	[[Category: ~~Lovestam, S.K.A~~]]	+	== References ==
-	[[Category: Huang, M]]	+	<references/>
-	[[Category: ~~Goedert, M~~]]	+	__TOC__
-	[[Category: ~~Schweighauser, M~~]]	+	</StructureSection>
-	[[Category: ~~Lavenir, I~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Kumar, A~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Graff, C~~]]	+	[[Category: Ghetti B]]
-	[[Category: ~~Yang, Y~~]]	+	[[Category: Goedert M]]
-	[[Category: ~~Scheres, S.H.W~~]]	+	[[Category: Graff C]]
-	[[Category: ~~Murzin, A.G~~]]	+	[[Category: Huang M]]
-	[[Category: ~~Zhang, W.J~~]]	+	[[Category: Kumar A]]
-	[[Category: ~~Macdonald, J~~]]	+	[[Category: Lavenir I]]
-	[[Category: ~~Nordber, A~~]]	+	[[Category: Lovestam SKA]]
		+	[[Category: Macdonald J]]
		+	[[Category: Murzin AG]]
		+	[[Category: Nordber A]]
		+	[[Category: Peak-Chew SY]]
		+	[[Category: Scheres SHW]]
		+	[[Category: Schweighauser M]]
		+	[[Category: Yang Y]]
		+	[[Category: Zhang WJ]]

OCA: Protected "8bg9" [edit=sysop:move=sysop]

OCA — Thu, 03 Nov 2022 05:13:37 GMT

Protected "8bg9" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 3 November 2022

OCA: New page: '''Unreleased structure''' The entry 8bg9 is ON HOLD Authors: Yang, Y., Zhang, W.J., Murzin, A.G., Schweighauser, M., Huang, M., Lovestam, S.K.A., Peak-Chew, S.Y., Macdonald, J., Laveni...

OCA — Thu, 03 Nov 2022 05:13:36 GMT

New page: '''Unreleased structure''' The entry 8bg9 is ON HOLD Authors: Yang, Y., Zhang, W.J., Murzin, A.G., Schweighauser, M., Huang, M., Lovestam, S.K.A., Peak-Chew, S.Y., Macdonald, J., Laveni...

New page

'''Unreleased structure'''

The entry 8bg9 is ON HOLD

Authors: Yang, Y., Zhang, W.J., Murzin, A.G., Schweighauser, M., Huang, M., Lovestam, S.K.A., Peak-Chew, S.Y., Macdonald, J., Lavenir, I., Ghetti, B., Graff, C., Kumar, A., Nordber, A., Goedert, M., Scheres, S.H.W.

Description: Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta
[[Category: Unreleased Structures]]
[[Category: Ghetti, B]]
[[Category: Peak-Chew, S.Y]]
[[Category: Lovestam, S.K.A]]
[[Category: Huang, M]]
[[Category: Goedert, M]]
[[Category: Schweighauser, M]]
[[Category: Lavenir, I]]
[[Category: Kumar, A]]
[[Category: Graff, C]]
[[Category: Yang, Y]]
[[Category: Scheres, S.H.W]]
[[Category: Murzin, A.G]]
[[Category: Zhang, W.J]]
[[Category: Macdonald, J]]
[[Category: Nordber, A]]

8bg9 - Revision history

OCA at 07:28, 18 January 2023

OCA: Protected "8bg9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bg9 is ON HOLD Authors: Yang, Y., Zhang, W.J., Murzin, A.G., Schweighauser, M., Huang, M., Lovestam, S.K.A., Peak-Chew, S.Y., Macdonald, J., Laveni...