OCA at 07:26, 22 November 2023

OCA — Wed, 22 Nov 2023 07:26:16 GMT

←Older revision		Revision as of 07:26, 22 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 8bjx is ON HOLD until Paper Publication~~	+	==Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide==
-		+	<StructureSection load='8bjx' size='340' side='right'caption='[[8bjx]], [[Resolution\|resolution]] 1.28Å' scene=''>
-	~~Authors: Angeli, A., Ferraroni, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bjx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BJX FirstGlance]. <br>
-	~~Description:~~ Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.283Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QKO:1-[(3~{R})-1-(6-nitropyridin-2-yl)pyrrolidin-3-yl]-3-(4-sulfamoylphenyl)thiourea'>QKO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: Angeli, A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bjx OCA], [https://pdbe.org/8bjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bjx RCSB], [https://www.ebi.ac.uk/pdbsum/8bjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bjx ProSAT]</span></td></tr>
-	[[Category: Ferraroni, M]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Angeli A]]
		+	[[Category: Ferraroni M]]

OCA at 07:18, 14 December 2022

OCA — Wed, 14 Dec 2022 07:18:51 GMT

←Older revision		Revision as of 07:18, 14 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bjx is ON HOLD	+	The entry 8bjx is ON HOLD until Paper Publication

	Authors: Angeli, A., Ferraroni, M.		Authors: Angeli, A., Ferraroni, M.
Line 7:		Line 7:
	Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide		Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ferraroni, M]]
	[[Category: Angeli, A]]		[[Category: Angeli, A]]
		+	[[Category: Ferraroni, M]]

OCA: Protected "8bjx" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2022 17:53:58 GMT

Protected "8bjx" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:53, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8bjx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nit...

OCA — Wed, 16 Nov 2022 17:53:57 GMT

New page: '''Unreleased structure''' The entry 8bjx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nit...

New page

'''Unreleased structure'''

The entry 8bjx is ON HOLD

Authors: Angeli, A., Ferraroni, M.

Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nitropyridin-2-yl)pyrrolidin-3-yl)thioureido)benzenesulfonamide
[[Category: Unreleased Structures]]
[[Category: Ferraroni, M]]
[[Category: Angeli, A]]

8bjx - Revision history

OCA at 07:26, 22 November 2023

OCA at 07:18, 14 December 2022

OCA: Protected "8bjx" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bjx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(3-(1-(6-nit...