OCA at 12:30, 4 October 2023

OCA — Wed, 04 Oct 2023 12:30:56 GMT

←Older revision		Revision as of 12:30, 4 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8blp is ~~ON HOLD until Paper Publication~~	+	==Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14==
-		+	<StructureSection load='8blp' size='340' side='right'caption='[[8blp]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8blp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BLP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5D3:10-(4-ethylphenyl)sulfonyl-~{N}-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine'>5D3</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8blp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8blp OCA], [https://pdbe.org/8blp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8blp RCSB], [https://www.ebi.ac.uk/pdbsum/8blp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8blp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/UT1_HUMAN UT1_HUMAN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith CH]]
		+	[[Category: Bohstedt T]]
		+	[[Category: Bountra C]]
		+	[[Category: Burgess-Brown NA]]
		+	[[Category: Chi G]]
		+	[[Category: Dietz L]]
		+	[[Category: Duerr KL]]
		+	[[Category: Edwards A]]
		+	[[Category: Fernandez-Cid A]]
		+	[[Category: Maclean EM]]
		+	[[Category: McKinley G]]
		+	[[Category: Mukhopadhyay SMM]]
		+	[[Category: Pike ACW]]
		+	[[Category: Scacioc A]]
		+	[[Category: Wang D]]

OCA at 07:20, 14 December 2022

OCA — Wed, 14 Dec 2022 07:20:01 GMT

←Older revision		Revision as of 07:20, 14 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8blp is ON HOLD	+	The entry 8blp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8blp" [edit=sysop:move=sysop]

OCA — Wed, 16 Nov 2022 17:58:52 GMT

Protected "8blp" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:58, 16 November 2022

OCA: New page: '''Unreleased structure''' The entry 8blp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Nov 2022 17:58:50 GMT

New page: '''Unreleased structure''' The entry 8blp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8blp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8blp - Revision history

OCA at 12:30, 4 October 2023

OCA at 07:20, 14 December 2022

OCA: Protected "8blp" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8blp is ON HOLD Authors: Description: Category: Unreleased Structures