8bof - Revision history

OCA at 08:19, 7 February 2024

OCA — Wed, 07 Feb 2024 08:19:10 GMT

←Older revision		Revision as of 08:19, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8bof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BOF FirstGlance]. <br>		<table><tr><td colspan='2'>[[8bof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BOF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R3L:4-methyl-~{N}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide'>R3L</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R3L:4-methyl-~{N}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide'>R3L</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bof OCA], [https://pdbe.org/8bof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bof RCSB], [https://www.ebi.ac.uk/pdbsum/8bof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bof ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bof OCA], [https://pdbe.org/8bof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bof RCSB], [https://www.ebi.ac.uk/pdbsum/8bof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bof ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:32, 8 March 2023

OCA — Wed, 08 Mar 2023 07:32:37 GMT

←Older revision		Revision as of 07:32, 8 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8bof is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12==
-		+	<StructureSection load='8bof' size='340' side='right'caption='[[8bof]], [[Resolution\|resolution]] 1.82Å' scene=''>
-	~~Authors~~: ~~Linhard~~, V., ~~Witt~~, K., ~~Gande~~, S., ~~Wollenhaupt~~, J., ~~Lennartz~~, F., ~~Weiss~~, M.S., ~~Schwalbe~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bof]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BOF FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R3L:4-methyl-~{N}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide'>R3L</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bof OCA], [https://pdbe.org/8bof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bof RCSB], [https://www.ebi.ac.uk/pdbsum/8bof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bof ProSAT]</span></td></tr>
-	[[Category: Gande, S]]	+	</table>
-	[[Category: ~~Witt, K~~]]	+	== Disease ==
-	[[Category: Linhard, V]]	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:[https://omim.org/entry/613020 613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.<ref>PMID:19573808</ref> <ref>PMID:19649315</ref> Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:[https://omim.org/entry/116600 116600]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.<ref>PMID:19573808</ref> <ref>PMID:19005574</ref> <ref>PMID:19306328</ref> <ref>PMID:22570727</ref> Note=Overexpressed in several cancer types and promotes malignancy.<ref>PMID:19573808</ref>
-	[[Category: Schwalbe, H]]	+	== Function ==
-	[[Category: ~~Lennartz, F~~]]	+	[https://www.uniprot.org/uniprot/EPHA2_HUMAN EPHA2_HUMAN] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.<ref>PMID:10655584</ref> <ref>PMID:16236711</ref> <ref>PMID:18339848</ref> <ref>PMID:19573808</ref> <ref>PMID:20679435</ref> <ref>PMID:20861311</ref>
-	[[Category: ~~Weiss, M.S~~]]	+	== References ==
-	[[Category: Wollenhaupt, J]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Gande S]]
		+	[[Category: Lennartz F]]
		+	[[Category: Linhard V]]
		+	[[Category: Schwalbe H]]
		+	[[Category: Weiss MS]]
		+	[[Category: Witt K]]
		+	[[Category: Wollenhaupt J]]

OCA at 05:23, 28 December 2022

OCA — Wed, 28 Dec 2022 05:23:54 GMT

←Older revision		Revision as of 05:23, 28 December 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bof is ON HOLD	+	The entry 8bof is ON HOLD until Paper Publication

	Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H.		Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H.
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	Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12		Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Linhard, V]]
-	[[Category: Wollenhaupt, J]]
	[[Category: Gande, S]]		[[Category: Gande, S]]
	[[Category: Witt, K]]		[[Category: Witt, K]]
		+	[[Category: Linhard, V]]
	[[Category: Schwalbe, H]]		[[Category: Schwalbe, H]]
	[[Category: Lennartz, F]]		[[Category: Lennartz, F]]
	[[Category: Weiss, M.S]]		[[Category: Weiss, M.S]]
		+	[[Category: Wollenhaupt, J]]

OCA: Protected "8bof" [edit=sysop:move=sysop]

OCA — Thu, 24 Nov 2022 08:03:38 GMT

Protected "8bof" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:03, 24 November 2022

OCA: New page: '''Unreleased structure''' The entry 8bof is ON HOLD Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H. Description: Crystal Structure ...

OCA — Thu, 24 Nov 2022 08:03:37 GMT

New page: '''Unreleased structure''' The entry 8bof is ON HOLD Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H. Description: Crystal Structure ...

New page

'''Unreleased structure'''

The entry 8bof is ON HOLD

Authors: Linhard, V., Witt, K., Gande, S., Wollenhaupt, J., Lennartz, F., Weiss, M.S., Schwalbe, H.

Description: Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 12
[[Category: Unreleased Structures]]
[[Category: Linhard, V]]
[[Category: Wollenhaupt, J]]
[[Category: Gande, S]]
[[Category: Witt, K]]
[[Category: Schwalbe, H]]
[[Category: Lennartz, F]]
[[Category: Weiss, M.S]]