OCA at 11:13, 14 March 2024

OCA — Thu, 14 Mar 2024 11:13:09 GMT

←Older revision		Revision as of 11:13, 14 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8bug is ~~ON HOLD until Paper Publication~~	+	==Structure of DDB1 bound to HQ461-engaged CDK12-cyclin K==
-		+	<StructureSection load='8bug' size='340' side='right'caption='[[8bug]], [[Resolution\|resolution]] 3.53Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bug]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BUG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.53Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=RPW:2-[2-[(6-methylpyridin-2-yl)amino]-1,3-thiazol-4-yl]-~{N}-(5-methyl-1,3-thiazol-2-yl)ethanamide'>RPW</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bug OCA], [https://pdbe.org/8bug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bug RCSB], [https://www.ebi.ac.uk/pdbsum/8bug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bug ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DDB1_HUMAN DDB1_HUMAN] Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.<ref>PMID:12732143</ref> <ref>PMID:15448697</ref> <ref>PMID:14739464</ref> <ref>PMID:15882621</ref> <ref>PMID:16260596</ref> <ref>PMID:16482215</ref> <ref>PMID:17079684</ref> <ref>PMID:16407242</ref> <ref>PMID:16407252</ref> <ref>PMID:16678110</ref> <ref>PMID:16940174</ref> <ref>PMID:17041588</ref> <ref>PMID:16473935</ref> <ref>PMID:18593899</ref> <ref>PMID:18381890</ref> <ref>PMID:18332868</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Focht V]]
		+	[[Category: Kempf G]]
		+	[[Category: Kozicka Z]]
		+	[[Category: Thoma NH]]

OCA at 05:24, 18 May 2023

OCA — Thu, 18 May 2023 05:24:30 GMT

←Older revision		Revision as of 05:24, 18 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bug is ON HOLD	+	The entry 8bug is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 18:34, 12 April 2023

OCA — Wed, 12 Apr 2023 18:34:02 GMT

←Older revision		Revision as of 18:34, 12 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bug is ON HOLD ~~until Paper Publication~~	+	The entry 8bug is ON HOLD

	Authors:		Authors:

OCA at 05:35, 11 January 2023

OCA — Wed, 11 Jan 2023 05:35:30 GMT

←Older revision		Revision as of 05:35, 11 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bug is ON HOLD	+	The entry 8bug is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8bug" [edit=sysop:move=sysop]

OCA — Wed, 07 Dec 2022 05:22:17 GMT

Protected "8bug" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 7 December 2022

OCA: New page: '''Unreleased structure''' The entry 8bug is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 07 Dec 2022 05:21:41 GMT

New page: '''Unreleased structure''' The entry 8bug is ON HOLD Authors: Description: Category: Unreleased Structures

New page