OCA at 06:11, 19 July 2023

OCA — Wed, 19 Jul 2023 06:11:17 GMT

←Older revision		Revision as of 06:11, 19 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8bw5 is ~~ON HOLD until Paper Publication~~	+	==X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer==
-		+	<StructureSection load='8bw5' size='340' side='right'caption='[[8bw5]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Troisi~~, R., ~~Napolitano~~, V., ~~Sica~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bw5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW5 FirstGlance]. <br>
-	~~Description~~: ~~X-ray structure~~ of the complex ~~between human alpha thrombin~~ and the ~~duplex~~/~~quadruplex aptamer M08s~~-~~1_41mer~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0G6:D-PHENYLALANYL-N-[(2S,3S)-6-{[AMINO(IMINIO)METHYL]AMINO}-1-CHLORO-2-HYDROXYHEXAN-3-YL]-L-PROLINAMIDE'>0G6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	[[Category: ~~Sica, F~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw5 OCA], [https://pdbe.org/8bw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw5 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw5 ProSAT]</span></td></tr>
-	[[Category: ~~Troisi, R~~]]	+	</table>
-	[[Category: Napolitano, V]]	+	== Disease ==
		+	[https://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[https://omim.org/entry/613679 613679]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[https://omim.org/entry/188050 188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[https://omim.org/entry/614390 614390]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Napolitano V]]
		+	[[Category: Sica F]]
		+	[[Category: Troisi R]]

OCA at 06:04, 21 December 2022

OCA — Wed, 21 Dec 2022 06:04:28 GMT

←Older revision		Revision as of 06:04, 21 December 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bw5 is ON HOLD	+	The entry 8bw5 is ON HOLD until Paper Publication

	Authors: Troisi, R., Napolitano, V., Sica, F.		Authors: Troisi, R., Napolitano, V., Sica, F.
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	Description: X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer		Description: X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Sica, F]]
	[[Category: Troisi, R]]		[[Category: Troisi, R]]
	[[Category: Napolitano, V]]		[[Category: Napolitano, V]]
-	[[Category: Sica, F]]

OCA: Protected "8bw5" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2022 07:25:47 GMT

Protected "8bw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 14 December 2022

OCA: New page: '''Unreleased structure''' The entry 8bw5 is ON HOLD Authors: Troisi, R., Napolitano, V., Sica, F. Description: X-ray structure of the complex between human alpha thrombin and the dupl...

OCA — Wed, 14 Dec 2022 07:25:44 GMT

New page: '''Unreleased structure''' The entry 8bw5 is ON HOLD Authors: Troisi, R., Napolitano, V., Sica, F. Description: X-ray structure of the complex between human alpha thrombin and the dupl...

New page

'''Unreleased structure'''

The entry 8bw5 is ON HOLD

Authors: Troisi, R., Napolitano, V., Sica, F.

Description: X-ray structure of the complex between human alpha thrombin and the duplex/quadruplex aptamer M08s-1_41mer
[[Category: Unreleased Structures]]
[[Category: Troisi, R]]
[[Category: Napolitano, V]]
[[Category: Sica, F]]

8bw5 - Revision history

OCA at 06:11, 19 July 2023

OCA at 06:04, 21 December 2022

OCA: Protected "8bw5" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bw5 is ON HOLD Authors: Troisi, R., Napolitano, V., Sica, F. Description: X-ray structure of the complex between human alpha thrombin and the dupl...