OCA at 12:41, 22 February 2023

OCA — Wed, 22 Feb 2023 12:41:51 GMT

←Older revision		Revision as of 12:41, 22 February 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8bxa is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of ribosome binding factor A (RbfA) from S. aureus==
		+	<StructureSection load='8bxa' size='340' side='right'caption='[[8bxa]], [[Resolution\|resolution]] 2.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8bxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BXA FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bxa OCA], [https://pdbe.org/8bxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bxa RCSB], [https://www.ebi.ac.uk/pdbsum/8bxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bxa ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RBFA_STAA8 RBFA_STAA8] One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.[HAMAP-Rule:MF_00003]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosome biogenesis is a complex and highly accurate conservative process of ribosomal subunit maturation followed by association. Subunit maturation comprises sequential stages of ribosomal RNA and proteins' folding, modification and binding, with the involvement of numerous RNAses, helicases, GTPases, chaperones, RNA, protein-modifying enzymes, and assembly factors. One such assembly factor involved in bacterial 30S subunit maturation is ribosomal binding factor A (RbfA). In this study, we present the crystal (determined at 2.2 A resolution) and NMR structures of RbfA as well as the 2.9 A resolution cryo-EM reconstruction of the 30S-RbfA complex from Staphylococcus aureus (S. aureus). Additionally, we show that the manner of RbfA action on the small ribosomal subunit during its maturation is shared between bacteria and mitochondria. The obtained results clarify the function of RbfA in the 30S maturation process and its role in ribosome functioning in general. Furthermore, given that S. aureus is a serious human pathogen, this study provides an additional prospect to develop antimicrobials targeting bacterial pathogens.

-	~~Authors~~:	+	Yet Another Similarity between Mitochondrial and Bacterial Ribosomal Small Subunit Biogenesis Obtained by Structural Characterization of RbfA from S. aureus.,Bikmullin AG, Fatkhullin B, Stetsenko A, Gabdulkhakov A, Garaeva N, Nurullina L, Klochkova E, Golubev A, Khusainov I, Trachtmann N, Blokhin D, Guskov A, Validov S, Usachev K, Yusupov M Int J Mol Sci. 2023 Jan 20;24(3):2118. doi: 10.3390/ijms24032118. PMID:36768442<ref>PMID:36768442</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8bxa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
		+	[[Category: Bikmullin A]]
		+	[[Category: Fatkhullin B]]
		+	[[Category: Gabdulkhakov A]]
		+	[[Category: Khusainov I]]
		+	[[Category: Usachev K]]
		+	[[Category: Validov S]]
		+	[[Category: Yusupov M]]

OCA at 05:38, 11 January 2023

OCA — Wed, 11 Jan 2023 05:38:31 GMT

←Older revision		Revision as of 05:38, 11 January 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bxa is ON HOLD	+	The entry 8bxa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8bxa" [edit=sysop:move=sysop]

OCA — Wed, 14 Dec 2022 07:30:12 GMT

Protected "8bxa" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:30, 14 December 2022

OCA: New page: '''Unreleased structure''' The entry 8bxa is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Dec 2022 07:30:11 GMT

New page: '''Unreleased structure''' The entry 8bxa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8bxa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8bxa - Revision history

OCA at 12:41, 22 February 2023

OCA at 05:38, 11 January 2023

OCA: Protected "8bxa" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bxa is ON HOLD Authors: Description: Category: Unreleased Structures