OCA at 07:29, 3 May 2023

OCA — Wed, 03 May 2023 07:29:20 GMT

←Older revision		Revision as of 07:29, 3 May 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8byq is ~~ON HOLD until Paper Publication~~	+	==RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W)==
-		+	<StructureSection load='8byq' size='340' side='right'caption='[[8byq]], [[Resolution\|resolution]] 4.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8byq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] and [https://en.wikipedia.org/wiki/Unidentified_adenovirus Unidentified adenovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BYQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8byq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8byq OCA], [https://pdbe.org/8byq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8byq RCSB], [https://www.ebi.ac.uk/pdbsum/8byq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8byq ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ERCC3_HUMAN ERCC3_HUMAN] IBIDS syndrome;Xeroderma pigmentosum complementation group B;PIBIDS syndrome;Xeroderma pigmentosum/Cockayne syndrome complex. Defects in ERCC3 are the cause of xeroderma pigmentosum complementation group B (XP-B) [MIM:[https://omim.org/entry/610651 610651]; also known as xeroderma pigmentosum II (XP2) or XP group B (XPB) or xeroderma pigmentosum group B combined with Cockayne syndrome (XP-B/CS). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-B patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.<ref>PMID:8304337</ref> <ref>PMID:16947863</ref> Defects in ERCC3 are a cause of trichothiodystrophy photosensitive (TTDP) [MIM:[https://omim.org/entry/601675 601675]. TTDP is an autosomal recessive disease characterized by sulfur-deficient brittle hair and nails, ichthyosis, mental retardation, impaired sexual development, abnormal facies and cutaneous photosensitivity correlated with a nucleotide excision repair (NER) defect. Neonates with trichothiodystrophy and ichthyosis are usually born with a collodion membrane. The severity of the ichthyosis after the membrane is shed is variable, ranging from a mild to severe lamellar ichthyotic phenotype. There are no reports of skin cancer associated with TTDP.<ref>PMID:9012405</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ERCC3_HUMAN ERCC3_HUMAN] ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.<ref>PMID:10024882</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Unidentified adenovirus]]
		+	[[Category: Abril-Garrido J]]
		+	[[Category: Cramer P]]
		+	[[Category: Dienemann C]]
		+	[[Category: Grabbe F]]
		+	[[Category: Lidschreiber M]]
		+	[[Category: Velychko T]]
		+	[[Category: Wang H]]

OCA at 04:44, 7 April 2023

OCA — Fri, 07 Apr 2023 04:44:01 GMT

←Older revision		Revision as of 04:44, 7 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8byq is ON HOLD	+	The entry 8byq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8byq" [edit=sysop:move=sysop]

OCA — Wed, 21 Dec 2022 06:11:55 GMT

Protected "8byq" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:11, 21 December 2022

OCA: New page: '''Unreleased structure''' The entry 8byq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Dec 2022 06:11:50 GMT

New page: '''Unreleased structure''' The entry 8byq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8byq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8byq - Revision history

OCA at 07:29, 3 May 2023

OCA at 04:44, 7 April 2023

OCA: Protected "8byq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8byq is ON HOLD Authors: Description: Category: Unreleased Structures