OCA at 23:10, 27 December 2023

OCA — Wed, 27 Dec 2023 23:10:09 GMT

←Older revision		Revision as of 23:10, 27 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8bzm is ~~ON HOLD until Paper Publication~~	+	==FOXK1-ELF1-heterodimer bound to DNA==
-		+	<StructureSection load='8bzm' size='340' side='right'caption='[[8bzm]], [[Resolution\|resolution]] 2.69Å' scene=''>
-	~~Authors~~: ~~Morgunova~~, E., ~~Popov~~, A., ~~Yin, Y~~., ~~Taipale, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8bzm]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BZM FirstGlance]. <br>
-	~~Description~~: ~~FOXK1~~-~~ELF1~~-~~heterodimer bound~~ to ~~DNA~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.69Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Taipale, J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bzm OCA], [https://pdbe.org/8bzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bzm RCSB], [https://www.ebi.ac.uk/pdbsum/8bzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bzm ProSAT]</span></td></tr>
-	[[Category: Popov, A]]	+	</table>
-	[[Category: ~~Morgunova, E~~]]	+	== Function ==
-	[[Category: Yin, Y]]	+	[https://www.uniprot.org/uniprot/FOXK1_HUMAN FOXK1_HUMAN] Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).[UniProtKB:P42128]<ref>PMID:17670796</ref> <ref>PMID:25805136</ref> <ref>PMID:25852164</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Morgunova E]]
		+	[[Category: Popov A]]
		+	[[Category: Taipale J]]
		+	[[Category: Yin Y]]

OCA at 04:49, 25 January 2023

OCA — Wed, 25 Jan 2023 04:49:21 GMT

←Older revision		Revision as of 04:49, 25 January 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8bzm is ON HOLD	+	The entry 8bzm is ON HOLD until Paper Publication

	Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J.		Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J.

OCA: Protected "8bzm" [edit=sysop:move=sysop]

OCA — Wed, 21 Dec 2022 06:15:50 GMT

Protected "8bzm" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 21 December 2022

OCA: New page: '''Unreleased structure''' The entry 8bzm is ON HOLD Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J. Description: FOXK1-ELF1-heterodimer bound to DNA [[Category: Unreleased Str...

OCA — Wed, 21 Dec 2022 06:15:47 GMT

New page: '''Unreleased structure''' The entry 8bzm is ON HOLD Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J. Description: FOXK1-ELF1-heterodimer bound to DNA [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 8bzm is ON HOLD

Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J.

Description: FOXK1-ELF1-heterodimer bound to DNA
[[Category: Unreleased Structures]]
[[Category: Taipale, J]]
[[Category: Popov, A]]
[[Category: Morgunova, E]]
[[Category: Yin, Y]]

8bzm - Revision history

OCA at 23:10, 27 December 2023

OCA at 04:49, 25 January 2023

OCA: Protected "8bzm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8bzm is ON HOLD Authors: Morgunova, E., Popov, A., Yin, Y., Taipale, J. Description: FOXK1-ELF1-heterodimer bound to DNA [[Category: Unreleased Str...