OCA at 13:50, 24 January 2024

OCA — Wed, 24 Jan 2024 13:50:48 GMT

←Older revision		Revision as of 13:50, 24 January 2024
Line 12:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>		[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+
		+	==See Also==
		+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:03, 17 January 2024

OCA — Wed, 17 Jan 2024 10:03:28 GMT

←Older revision		Revision as of 10:03, 17 January 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8c85 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1==
-		+	<StructureSection load='8c85' size='340' side='right'caption='[[8c85]], [[Resolution\|resolution]] 1.19Å' scene=''>
-	~~Authors~~: ~~Poonsiri~~, T., ~~Benini~~, S., ~~Loconte~~, V., ~~Cianci, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8c85]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C85 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~human~~ transthyretin ~~in complex with 3~~-O-~~methyltolcapone analogue~~ 1	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.19Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U1F:(3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone'>U1F</scene></td></tr>
-	[[Category: ~~Cianci, M~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c85 OCA], [https://pdbe.org/8c85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c85 RCSB], [https://www.ebi.ac.uk/pdbsum/8c85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c85 ProSAT]</span></td></tr>
-	[[Category: ~~Poonsiri, T~~]]	+	</table>
-	[[Category: Loconte, V]]	+	== Disease ==
-	[[Category: ~~Benini, S~~]]	+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Benini S]]
		+	[[Category: Cianci M]]
		+	[[Category: Loconte V]]
		+	[[Category: Poonsiri T]]

OCA at 09:21, 22 February 2023

OCA — Wed, 22 Feb 2023 09:21:35 GMT

←Older revision		Revision as of 09:21, 22 February 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8c85 is ON HOLD	+	The entry 8c85 is ON HOLD until Paper Publication

	Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M.		Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M.
Line 7:		Line 7:
	Description: Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1		Description: Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Cianci, M]]
	[[Category: Poonsiri, T]]		[[Category: Poonsiri, T]]
	[[Category: Loconte, V]]		[[Category: Loconte, V]]
	[[Category: Benini, S]]		[[Category: Benini, S]]
-	[[Category: Cianci, M]]

OCA: Protected "8c85" [edit=sysop:move=sysop]

OCA — Wed, 25 Jan 2023 04:53:24 GMT

Protected "8c85" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 25 January 2023

OCA: New page: '''Unreleased structure''' The entry 8c85 is ON HOLD Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M. Description: Crystal structure of human transthyretin in complex with 3-...

OCA — Wed, 25 Jan 2023 04:53:23 GMT

New page: '''Unreleased structure''' The entry 8c85 is ON HOLD Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M. Description: Crystal structure of human transthyretin in complex with 3-...

New page

'''Unreleased structure'''

The entry 8c85 is ON HOLD

Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M.

Description: Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1
[[Category: Unreleased Structures]]
[[Category: Poonsiri, T]]
[[Category: Loconte, V]]
[[Category: Benini, S]]
[[Category: Cianci, M]]

8c85 - Revision history

OCA at 13:50, 24 January 2024

OCA at 10:03, 17 January 2024

OCA at 09:21, 22 February 2023

OCA: Protected "8c85" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8c85 is ON HOLD Authors: Poonsiri, T., Benini, S., Loconte, V., Cianci, M. Description: Crystal structure of human transthyretin in complex with 3-...