OCA at 05:40, 5 July 2023

OCA — Wed, 05 Jul 2023 05:40:19 GMT

←Older revision		Revision as of 05:40, 5 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8c8t is ~~ON HOLD until 2025~~-01-21	+	==cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117==
-		+	<StructureSection load='8c8t' size='340' side='right'caption='[[8c8t]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8c8t]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8T FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8t OCA], [https://pdbe.org/8c8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8t RCSB], [https://www.ebi.ac.uk/pdbsum/8c8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8t ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2N0S5_9HIV1 Q2N0S5_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292][SAAS:SAAS00139820] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.[SAAS:SAAS00140087]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
		+	[[Category: Baquero E]]
		+	[[Category: Molinos-Albert L]]
		+	[[Category: Mouquet H]]

OCA at 04:15, 2 March 2023

OCA — Thu, 02 Mar 2023 04:15:35 GMT

←Older revision		Revision as of 04:15, 2 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8c8t is ON HOLD	+	The entry 8c8t is ON HOLD until 2025-01-21

	Authors:		Authors:

OCA: Protected "8c8t" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2023 09:10:10 GMT

Protected "8c8t" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:10, 1 February 2023

OCA: New page: '''Unreleased structure''' The entry 8c8t is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Feb 2023 09:10:08 GMT

New page: '''Unreleased structure''' The entry 8c8t is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8c8t is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8c8t - Revision history

OCA at 05:40, 5 July 2023

OCA at 04:15, 2 March 2023

OCA: Protected "8c8t" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8c8t is ON HOLD Authors: Description: Category: Unreleased Structures