OCA at 12:31, 4 October 2023

OCA — Wed, 04 Oct 2023 12:31:31 GMT

←Older revision		Revision as of 12:31, 4 October 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8cad is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of the Ceres homohexamer from Galleria mellonella saliva==
		+	<StructureSection load='8cad' size='340' side='right'caption='[[8cad]], [[Resolution\|resolution]] 2.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8cad]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Galleria_mellonella Galleria mellonella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CAD FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cad OCA], [https://pdbe.org/8cad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cad RCSB], [https://www.ebi.ac.uk/pdbsum/8cad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cad ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A6J1WN20_GALME A0A6J1WN20_GALME]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plastic waste management is a pressing ecological, social, and economic challenge. The saliva of the lepidopteran Galleria mellonella larvae is capable of oxidizing and depolymerizing polyethylene in hours at room temperature. Here, we analyze by cryo-electron microscopy (cryo-EM) G. mellonella's saliva directly from the native source. The three-dimensional reconstructions reveal that the buccal secretion is mainly composed of four hexamerins belonging to the hemocyanin/phenoloxidase family, renamed Demetra, Cibeles, Ceres, and a previously unidentified factor termed Cora. Functional assays show that this factor, as its counterparts Demetra and Ceres, is also able to oxidize and degrade polyethylene. The cryo-EM data and the x-ray analysis from purified fractions show that they self-assemble primarily into three macromolecular complexes with striking structural differences that likely modulate their activity. Overall, these results establish the ground to further explore the hexamerins' functionalities, their role in vivo, and their eventual biotechnological application.

-	~~Authors~~:	+	Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva.,Spinola-Amilibia M, Illanes-Vicioso R, Ruiz-L Formula See Text Pez E, Colomer-Vidal P, Rodriguez FV, Peces Perez R, Arias CF, Torroba T, Sol Formula See Text M, Arias-Palomo E, Bertocchini F Sci Adv. 2023 Sep 22;9(38):eadi6813. doi: 10.1126/sciadv.adi6813. Epub 2023 Sep , 20. PMID:37729416<ref>PMID:37729416</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8cad" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Galleria mellonella]]
		+	[[Category: Large Structures]]
		+	[[Category: Arias-Palomo E]]
		+	[[Category: Spinola-Amilibia M]]

OCA at 04:58, 10 May 2023

OCA — Wed, 10 May 2023 04:58:47 GMT

←Older revision		Revision as of 04:58, 10 May 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cad is ON HOLD	+	The entry 8cad is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8cad" [edit=sysop:move=sysop]

OCA — Wed, 01 Feb 2023 09:14:43 GMT

Protected "8cad" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:14, 1 February 2023

OCA: New page: '''Unreleased structure''' The entry 8cad is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 Feb 2023 09:14:41 GMT

New page: '''Unreleased structure''' The entry 8cad is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8cad is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8cad - Revision history

OCA at 12:31, 4 October 2023

OCA at 04:58, 10 May 2023

OCA: Protected "8cad" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8cad is ON HOLD Authors: Description: Category: Unreleased Structures