OCA at 12:35, 26 July 2023

OCA — Wed, 26 Jul 2023 12:35:57 GMT

←Older revision		Revision as of 12:35, 26 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8cgr is ~~ON HOLD~~	+	==Apramycin bound to the 30S body==
-		+	<StructureSection load='8cgr' size='340' side='right'caption='[[8cgr]], [[Resolution\|resolution]] 2.12Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8cgr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BW25113 Escherichia coli BW25113]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CGR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.12Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=4OC:4N,O2-METHYLCYTIDINE-5-MONOPHOSPHATE'>4OC</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=AM2:APRAMYCIN'>AM2</scene>, <scene name='pdbligand=D2T:(3R)-3-(METHYLSULFANYL)-L-ASPARTIC+ACID'>D2T</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=IAS:BETA-L-ASPARTIC+ACID'>IAS</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MA6:6N-DIMETHYLADENOSINE-5-MONOPHOSHATE'>MA6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cgr OCA], [https://pdbe.org/8cgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cgr RCSB], [https://www.ebi.ac.uk/pdbsum/8cgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cgr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RS4_ECOLI RS4_ECOLI] One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref> Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase.<ref>PMID:2461734</ref> <ref>PMID:11447122</ref> <ref>PMID:15652481</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli BW25113]]
		+	[[Category: Large Structures]]
		+	[[Category: Beckert B]]
		+	[[Category: Koller TO]]
		+	[[Category: Paternoga H]]
		+	[[Category: Wilson DN]]

OCA at 04:34, 19 July 2023

OCA — Wed, 19 Jul 2023 04:34:47 GMT

←Older revision		Revision as of 04:34, 19 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cgr is ON HOLD ~~until Paper Publication~~	+	The entry 8cgr is ON HOLD

	Authors:		Authors:

OCA at 04:45, 7 April 2023

OCA — Fri, 07 Apr 2023 04:45:30 GMT

←Older revision		Revision as of 04:45, 7 April 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cgr is ON HOLD	+	The entry 8cgr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 04:18, 2 March 2023

OCA — Thu, 02 Mar 2023 04:18:33 GMT

←Older revision		Revision as of 04:18, 2 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cgr is ON HOLD ~~until sometime in the future~~	+	The entry 8cgr is ON HOLD

	Authors:		Authors:

OCA: Protected "8cgr" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 08:35:24 GMT

Protected "8cgr" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:35, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8cgr is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Feb 2023 08:35:23 GMT

New page: '''Unreleased structure''' The entry 8cgr is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page