OCA at 06:19, 6 September 2023

OCA — Wed, 06 Sep 2023 06:19:46 GMT

←Older revision		Revision as of 06:19, 6 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8chl is ~~ON HOLD until Paper Publication~~	+	==Human FKBP12 in complex with (1S,5S,6R)-9-((3,5-dichlorophenyl)sulfonyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,9-diazabicyclo[4.2.1]nonan-2-one==
-		+	<StructureSection load='8chl' size='340' side='right'caption='[[8chl]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8chl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CHL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=USV:(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one'>USV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8chl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8chl OCA], [https://pdbe.org/8chl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8chl RCSB], [https://www.ebi.ac.uk/pdbsum/8chl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8chl ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Hausch F]]
		+	[[Category: Meyners C]]
		+	[[Category: Purder PL]]

OCA at 09:27, 22 February 2023

OCA — Wed, 22 Feb 2023 09:27:18 GMT

←Older revision		Revision as of 09:27, 22 February 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8chl is ON HOLD	+	The entry 8chl is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8chl" [edit=sysop:move=sysop]

OCA — Wed, 15 Feb 2023 08:37:46 GMT

Protected "8chl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 15 February 2023

OCA: New page: '''Unreleased structure''' The entry 8chl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Feb 2023 08:37:46 GMT

New page: '''Unreleased structure''' The entry 8chl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8chl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8chl - Revision history

OCA at 06:19, 6 September 2023

OCA at 09:27, 22 February 2023

OCA: Protected "8chl" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8chl is ON HOLD Authors: Description: Category: Unreleased Structures