OCA at 23:10, 27 December 2023

OCA — Wed, 27 Dec 2023 23:10:37 GMT

←Older revision		Revision as of 23:10, 27 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8cn9 is ~~ON HOLD until Paper Publication~~	+	==Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII==
-		+	<StructureSection load='8cn9' size='340' side='right'caption='[[8cn9]], [[Resolution\|resolution]] 3.40Å' scene=''>
-	~~Authors~~: ~~Schluckebier~~, G., ~~Johansson~~, E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8cn9]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CN9 FirstGlance]. <br>
-	~~Description~~: ~~Factor VII binding Fab~~ of the ~~bispecific antibody HMB-001~~ in ~~complex~~ with Factor VII	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CS:CESIUM+ION'>CS</scene></td></tr>
-	[[Category: Johansson, E]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cn9 OCA], [https://pdbe.org/8cn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cn9 RCSB], [https://www.ebi.ac.uk/pdbsum/8cn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cn9 ProSAT]</span></td></tr>
-	[[Category: Schluckebier, G]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Johansson E]]
		+	[[Category: Schluckebier G]]

OCA at 04:48, 7 April 2023

OCA — Fri, 07 Apr 2023 04:48:11 GMT

←Older revision		Revision as of 04:48, 7 April 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cn9 is ON HOLD	+	The entry 8cn9 is ON HOLD until Paper Publication

	Authors: Schluckebier, G., Johansson, E.		Authors: Schluckebier, G., Johansson, E.

OCA at 05:33, 8 March 2023

OCA — Wed, 08 Mar 2023 05:33:50 GMT

←Older revision		Revision as of 05:33, 8 March 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cn9 is ON HOLD ~~until sometime in the future~~	+	The entry 8cn9 is ON HOLD

	Authors: Schluckebier, G., Johansson, E.		Authors: Schluckebier, G., Johansson, E.

OCA: Protected "8cn9" [edit=sysop:move=sysop]

OCA — Thu, 02 Mar 2023 04:22:43 GMT

Protected "8cn9" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:22, 2 March 2023

OCA: New page: '''Unreleased structure''' The entry 8cn9 is ON HOLD until sometime in the future Authors: Schluckebier, G., Johansson, E. Description: Factor VII binding Fab of the bispecific antibod...

OCA — Thu, 02 Mar 2023 04:22:41 GMT

New page: '''Unreleased structure''' The entry 8cn9 is ON HOLD until sometime in the future Authors: Schluckebier, G., Johansson, E. Description: Factor VII binding Fab of the bispecific antibod...

New page

'''Unreleased structure'''

The entry 8cn9 is ON HOLD until sometime in the future

Authors: Schluckebier, G., Johansson, E.

Description: Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII
[[Category: Unreleased Structures]]
[[Category: Johansson, E]]
[[Category: Schluckebier, G]]

8cn9 - Revision history

OCA at 23:10, 27 December 2023

OCA at 04:48, 7 April 2023

OCA at 05:33, 8 March 2023

OCA: Protected "8cn9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8cn9 is ON HOLD until sometime in the future Authors: Schluckebier, G., Johansson, E. Description: Factor VII binding Fab of the bispecific antibod...