8cpe - Revision history

OCA at 08:21, 16 August 2023

OCA — Wed, 16 Aug 2023 08:21:46 GMT

←Older revision		Revision as of 08:21, 16 August 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8cpe is ~~ON HOLD until Paper~~ Publication	+	==CryoEM structure of AL55 amyloid fibrils extracted from the kidney of an AL amyloidosis patient.==
		+	<StructureSection load='8cpe' size='340' side='right'caption='[[8cpe]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8cpe]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CPE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CPE FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cpe OCA], [https://pdbe.org/8cpe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cpe RCSB], [https://www.ebi.ac.uk/pdbsum/8cpe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cpe ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Immunoglobulin light chain amyloidosis (AL) is caused by the aberrant production of amyloidogenic light chains (LC) that accumulate as amyloid deposits in vital organs. Distinct LC sequences in each patient yield distinct amyloid structures. However different tissue microenvironments may also cause identical protein precursors to adopt distinct amyloid structures. To address the impact of the tissue environment on the structural polymorphism of amyloids, we extracted fibrils from the kidney of an AL patient (AL55) whose cardiac amyloid structure was previously determined by our group. Here we show that the 4.0 A resolution cryo-EM structure of the renal fibril is virtually identical to that reported for the cardiac fibril. These results provide the first structural evidence that LC amyloids independently deposited in different organs of the same AL patient share a common fold.

-	~~Authors: Puri~~, S., Schulte, T., Chaves-Sanjuan, A., ~~Ricagno~~, S.	+	The Cryo-EM STRUCTURE of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis.,Puri S, Schulte T, Chaves-Sanjuan A, Mazzini G, Caminito S, Pappone C, Anastasia L, Milani P, Merlini G, Bolognesi M, Nuvolone M, Palladini G, Ricagno S J Mol Biol. 2023 Jul 27;435(18):168215. doi: 10.1016/j.jmb.2023.168215. PMID:37516426<ref>PMID:37516426</ref>

-	~~Description: CryoEM structure~~ of ~~AL55 amyloid fibrils extracted from~~ the ~~kidney~~ of ~~an AL amyloidosis patient~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Chaves-Sanjuan, A]]	+	<div class="pdbe-citations 8cpe" style="background-color:#fffaf0;"></div>
-	[[Category: Puri, S]]	+	== References ==
-	[[Category: ~~Schulte, T~~]]	+	<references/>
-	[[Category: ~~Ricagno, S~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chaves-Sanjuan A]]
		+	[[Category: Puri S]]
		+	[[Category: Ricagno S]]
		+	[[Category: Schulte T]]

OCA at 05:20, 3 May 2023

OCA — Wed, 03 May 2023 05:20:39 GMT

←Older revision		Revision as of 05:20, 3 May 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cpe is ON HOLD	+	The entry 8cpe is ON HOLD until Paper Publication

	Authors: Puri, S., Schulte, T., Chaves-Sanjuan, A., Ricagno, S.		Authors: Puri, S., Schulte, T., Chaves-Sanjuan, A., Ricagno, S.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Chaves-Sanjuan, A]]		[[Category: Chaves-Sanjuan, A]]
-	[[Category: Schulte, T]]
	[[Category: Puri, S]]		[[Category: Puri, S]]
		+	[[Category: Schulte, T]]
	[[Category: Ricagno, S]]		[[Category: Ricagno, S]]

OCA at 07:32, 15 March 2023

OCA — Wed, 15 Mar 2023 07:32:07 GMT

←Older revision		Revision as of 07:32, 15 March 2023
Line 3:		Line 3:
	The entry 8cpe is ON HOLD		The entry 8cpe is ON HOLD

-	Authors: Puri, S., Schulte, T., Chaves Sanjuan, A., Ricagno, S.	+	Authors: Puri, S., Schulte, T., Chaves-Sanjuan, A., Ricagno, S.

	Description: CryoEM structure of AL55 amyloid fibrils extracted from the kidney of an AL amyloidosis patient.		Description: CryoEM structure of AL55 amyloid fibrils extracted from the kidney of an AL amyloidosis patient.
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Puri~~, S]]	+	[[Category: Chaves-Sanjuan, A]]
	[[Category: Schulte, T]]		[[Category: Schulte, T]]
		+	[[Category: Puri, S]]
	[[Category: Ricagno, S]]		[[Category: Ricagno, S]]
-	[[Category: Chaves Sanjuan, A]]

OCA: Protected "8cpe" [edit=sysop:move=sysop]

OCA — Wed, 08 Mar 2023 05:40:55 GMT

Protected "8cpe" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 8 March 2023

OCA: New page: '''Unreleased structure''' The entry 8cpe is ON HOLD Authors: Puri, S., Schulte, T., Chaves Sanjuan, A., Ricagno, S. Description: CryoEM structure of AL55 amyloid fibrils extracted fro...

OCA — Wed, 08 Mar 2023 05:40:54 GMT

New page: '''Unreleased structure''' The entry 8cpe is ON HOLD Authors: Puri, S., Schulte, T., Chaves Sanjuan, A., Ricagno, S. Description: CryoEM structure of AL55 amyloid fibrils extracted fro...

New page

'''Unreleased structure'''

The entry 8cpe is ON HOLD

Authors: Puri, S., Schulte, T., Chaves Sanjuan, A., Ricagno, S.

Description: CryoEM structure of AL55 amyloid fibrils extracted from the kidney of an AL amyloidosis patient.
[[Category: Unreleased Structures]]
[[Category: Puri, S]]
[[Category: Schulte, T]]
[[Category: Ricagno, S]]
[[Category: Chaves Sanjuan, A]]