OCA at 04:50, 8 September 2022

OCA — Thu, 08 Sep 2022 04:50:32 GMT

←Older revision		Revision as of 04:50, 8 September 2022
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-	====	+	==Composite reconstruction of Class 1 of the erythrocyte ankyrin-1 complex==
-	<StructureSection load='8cs9' size='340' side='right'caption='[[8cs9]]' scene=''>	+	<StructureSection load='8cs9' size='340' side='right'caption='[[8cs9]], [[Resolution\|resolution]] 2.74Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8cs9]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CS9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cs9 OCA], [https://pdbe.org/8cs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cs9 RCSB], [https://www.ebi.ac.uk/pdbsum/8cs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cs9 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cs9 OCA], [https://pdbe.org/8cs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cs9 RCSB], [https://www.ebi.ac.uk/pdbsum/8cs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cs9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN]] Defects in ANK1 are a cause of spherocytosis type 1 (SPH1) [MIM:[https://omim.org/entry/182900 182900]]; also called hereditary spherocytosis type 1 (HS1). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Inheritance can be autosomal dominant or recessive.<ref>PMID:8640229</ref> <ref>PMID:11102985</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/ANK1_HUMAN ANK1_HUMAN]] Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.<ref>PMID:12456646</ref> Isoform Mu17 together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.<ref>PMID:12456646</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhesus glycoproteins remains unknown. Here we present structures of ankyrin-1 complexes purified from human erythrocytes. We reveal the architecture of a core complex of ankyrin-1, the Rhesus proteins RhAG and RhCE, the band 3 anion exchanger, protein 4.2, glycophorin A and glycophorin B. The distinct T-shaped conformation of membrane-bound ankyrin-1 facilitates recognition of RhCE and, unexpectedly, the water channel aquaporin-1. Together, our results uncover the molecular details of ankyrin-1 association with the erythrocyte membrane, and illustrate the mechanism of ankyrin-mediated membrane protein clustering.
		+
		+	Architecture of the human erythrocyte ankyrin-1 complex.,Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w., Epub 2022 Jul 14. PMID:35835865<ref>PMID:35835865</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8cs9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Cali T]]
		+	[[Category: Clarke OB]]
		+	[[Category: Johnston JD]]
		+	[[Category: Kim K]]
		+	[[Category: Noble AJ]]
		+	[[Category: Vallese F]]
		+	[[Category: Yen LY]]

OCA at 06:59, 20 July 2022

OCA — Wed, 20 Jul 2022 06:59:11 GMT

←Older revision		Revision as of 06:59, 20 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8cs9 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='8cs9' size='340' side='right'caption='[[8cs9]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cs9 OCA], [https://pdbe.org/8cs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cs9 RCSB], [https://www.ebi.ac.uk/pdbsum/8cs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cs9 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:08, 15 June 2022

OCA — Wed, 15 Jun 2022 04:08:23 GMT

←Older revision		Revision as of 04:08, 15 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cs9 is ON HOLD	+	The entry 8cs9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8cs9" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2022 09:23:45 GMT

Protected "8cs9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:23, 18 May 2022

OCA: New page: '''Unreleased structure''' The entry 8cs9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 May 2022 09:23:44 GMT

New page: '''Unreleased structure''' The entry 8cs9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8cs9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8cs9 - Revision history

OCA at 04:50, 8 September 2022

OCA at 06:59, 20 July 2022

OCA at 04:08, 15 June 2022

OCA: Protected "8cs9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8cs9 is ON HOLD Authors: Description: Category: Unreleased Structures