8csx - Revision history

OCA at 09:40, 14 February 2024

OCA — Wed, 14 Feb 2024 09:40:49 GMT

←Older revision		Revision as of 09:40, 14 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8csx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSX FirstGlance]. <br>		<table><tr><td colspan='2'>[[8csx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csx OCA], [https://pdbe.org/8csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csx RCSB], [https://www.ebi.ac.uk/pdbsum/8csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csx OCA], [https://pdbe.org/8csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csx RCSB], [https://www.ebi.ac.uk/pdbsum/8csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN]] Rh deficiency syndrome. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN] Rh deficiency syndrome. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN]] May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.	+	[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN] May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhesus glycoproteins remains unknown. Here we present structures of ankyrin-1 complexes purified from human erythrocytes. We reveal the architecture of a core complex of ankyrin-1, the Rhesus proteins RhAG and RhCE, the band 3 anion exchanger, protein 4.2, glycophorin A and glycophorin B. The distinct T-shaped conformation of membrane-bound ankyrin-1 facilitates recognition of RhCE and, unexpectedly, the water channel aquaporin-1. Together, our results uncover the molecular details of ankyrin-1 association with the erythrocyte membrane, and illustrate the mechanism of ankyrin-mediated membrane protein clustering.	+
-		+
-	Architecture of the human erythrocyte ankyrin-1 complex.,Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w., Epub 2022 Jul 14. PMID:35835865<ref>PMID:35835865</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 8csx" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 04:50, 8 September 2022

OCA — Thu, 08 Sep 2022 04:50:45 GMT

←Older revision		Revision as of 04:50, 8 September 2022
Line 1:		Line 1:

-	====	+	==Local refinement of RhAG/CE trimer in class 2 of erythrocyte ankyrin-1 complex==
-	<StructureSection load='8csx' size='340' side='right'caption='[[8csx]]' scene=''>	+	<StructureSection load='8csx' size='340' side='right'caption='[[8csx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8csx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CSX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csx OCA], [https://pdbe.org/8csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csx RCSB], [https://www.ebi.ac.uk/pdbsum/8csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csx ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csx OCA], [https://pdbe.org/8csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csx RCSB], [https://www.ebi.ac.uk/pdbsum/8csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN]] Rh deficiency syndrome. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/RHCE_HUMAN RHCE_HUMAN]] May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The stability and shape of the erythrocyte membrane is provided by the ankyrin-1 complex, but how it tethers the spectrin-actin cytoskeleton to the lipid bilayer and the nature of its association with the band 3 anion exchanger and the Rhesus glycoproteins remains unknown. Here we present structures of ankyrin-1 complexes purified from human erythrocytes. We reveal the architecture of a core complex of ankyrin-1, the Rhesus proteins RhAG and RhCE, the band 3 anion exchanger, protein 4.2, glycophorin A and glycophorin B. The distinct T-shaped conformation of membrane-bound ankyrin-1 facilitates recognition of RhCE and, unexpectedly, the water channel aquaporin-1. Together, our results uncover the molecular details of ankyrin-1 association with the erythrocyte membrane, and illustrate the mechanism of ankyrin-mediated membrane protein clustering.
		+
		+	Architecture of the human erythrocyte ankyrin-1 complex.,Vallese F, Kim K, Yen LY, Johnston JD, Noble AJ, Cali T, Clarke OB Nat Struct Mol Biol. 2022 Jul;29(7):706-718. doi: 10.1038/s41594-022-00792-w., Epub 2022 Jul 14. PMID:35835865<ref>PMID:35835865</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8csx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Cali T]]
		+	[[Category: Clarke OB]]
		+	[[Category: Johnston JD]]
		+	[[Category: Kim K]]
		+	[[Category: Noble AJ]]
		+	[[Category: Vallese F]]
		+	[[Category: Yen LY]]

OCA at 06:59, 20 July 2022

OCA — Wed, 20 Jul 2022 06:59:22 GMT

←Older revision		Revision as of 06:59, 20 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8csx ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='8csx' size='340' side='right'caption='[[8csx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8csx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8csx OCA], [https://pdbe.org/8csx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8csx RCSB], [https://www.ebi.ac.uk/pdbsum/8csx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8csx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:22, 22 June 2022

OCA — Wed, 22 Jun 2022 07:22:57 GMT

←Older revision		Revision as of 07:22, 22 June 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8csx is ON HOLD	+	The entry 8csx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8csx" [edit=sysop:move=sysop]

OCA — Wed, 25 May 2022 06:58:21 GMT

Protected "8csx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 25 May 2022

OCA: New page: '''Unreleased structure''' The entry 8csx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 May 2022 06:58:20 GMT

New page: '''Unreleased structure''' The entry 8csx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8csx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]