8cxq - Revision history

OCA at 06:30, 8 September 2022

OCA — Thu, 08 Sep 2022 06:30:23 GMT

←Older revision		Revision as of 06:30, 8 September 2022
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-	====	+	==SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22==
-	<StructureSection load='8cxq' size='340' side='right'caption='[[8cxq]]' scene=''>	+	<StructureSection load='8cxq' size='340' side='right'caption='[[8cxq]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8cxq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXQ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxq OCA], [https://pdbe.org/8cxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxq RCSB], [https://www.ebi.ac.uk/pdbsum/8cxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxq ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxq OCA], [https://pdbe.org/8cxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxq RCSB], [https://www.ebi.ac.uk/pdbsum/8cxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Huang W]]
		+	[[Category: Taylor D]]

OCA at 16:16, 6 July 2022

OCA — Wed, 06 Jul 2022 16:16:30 GMT

←Older revision		Revision as of 16:16, 6 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8cxq ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='8cxq' size='340' side='right'caption='[[8cxq]]' scene=''>
-	~~Authors~~: ~~Huang, W~~.~~, Taylor, D~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: SARS~~-~~CoV-2 Spike protein in complex with~~ a ~~pan-sarbecovirus nanobody 1-22~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxq OCA], [https://pdbe.org/8cxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxq RCSB], [https://www.ebi.ac.uk/pdbsum/8cxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxq ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Huang, W~~]]	+	__TOC__
-	[[Category: ~~Taylor, D~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 06:25, 29 June 2022

OCA — Wed, 29 Jun 2022 06:25:03 GMT

←Older revision		Revision as of 06:25, 29 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8cxq is ON HOLD	+	The entry 8cxq is ON HOLD until Paper Publication

	Authors: Huang, W., Taylor, D.		Authors: Huang, W., Taylor, D.

OCA: Protected "8cxq" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:26:46 GMT

Protected "8cxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:26, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 8cxq is ON HOLD Authors: Huang, W., Taylor, D. Description: SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22 [[Category: U...

OCA — Wed, 08 Jun 2022 04:26:45 GMT

New page: '''Unreleased structure''' The entry 8cxq is ON HOLD Authors: Huang, W., Taylor, D. Description: SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22 [[Category: U...

New page

'''Unreleased structure'''

The entry 8cxq is ON HOLD

Authors: Huang, W., Taylor, D.

Description: SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 1-22
[[Category: Unreleased Structures]]
[[Category: Huang, W]]
[[Category: Taylor, D]]