8czq - Revision history

OCA at 10:04, 25 October 2023

OCA — Wed, 25 Oct 2023 10:04:43 GMT

←Older revision		Revision as of 10:04, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8czq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[8czq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czq OCA], [https://pdbe.org/8czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czq RCSB], [https://www.ebi.ac.uk/pdbsum/8czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czq OCA], [https://pdbe.org/8czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czq RCSB], [https://www.ebi.ac.uk/pdbsum/8czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:09, 14 December 2022

OCA — Wed, 14 Dec 2022 10:09:29 GMT

←Older revision		Revision as of 10:09, 14 December 2022
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-	'''Unreleased structure'''

-	The ~~entry~~ 8czq ~~is ON HOLD until Paper Publication~~	+	==The crystal structure of MtbTOP1 in complex with both G- and T-segments==
-		+	<StructureSection load='8czq' size='340' side='right'caption='[[8czq]], [[Resolution\|resolution]] 2.78Å' scene=''>
-	~~Authors~~: ~~Tan~~, K., ~~Tse~~-~~Dinh~~, Y.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8czq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZQ FirstGlance]. <br>
-	~~Description~~: The ~~crystal structure~~ of ~~MtbTOP1~~ in ~~complex with both G~~-and T-~~segments~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czq OCA], [https://pdbe.org/8czq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czq RCSB], [https://www.ebi.ac.uk/pdbsum/8czq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czq ProSAT]</span></td></tr>
-	[[Category: ~~Tse-Dinh, Y.C~~]]	+	</table>
-	[[Category: Tan, K]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0E8VY41_MYCTX A0A0E8VY41_MYCTX] Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.[HAMAP-Rule:MF_00952]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Tan K]]
		+	[[Category: Tse-Dinh Y-C]]

OCA at 03:59, 10 August 2022

OCA — Wed, 10 Aug 2022 03:59:25 GMT

←Older revision		Revision as of 03:59, 10 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8czq is ON HOLD	+	The entry 8czq is ON HOLD until Paper Publication

	Authors: Tan, K., Tse-Dinh, Y.C.		Authors: Tan, K., Tse-Dinh, Y.C.

OCA: Protected "8czq" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:29:41 GMT

Protected "8czq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:29, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 8czq is ON HOLD Authors: Tan, K., Tse-Dinh, Y.C. Description: The crystal structure of MtbTOP1 in complex with both G-and T-segments [[Category: Un...

OCA — Wed, 08 Jun 2022 04:29:40 GMT

New page: '''Unreleased structure''' The entry 8czq is ON HOLD Authors: Tan, K., Tse-Dinh, Y.C. Description: The crystal structure of MtbTOP1 in complex with both G-and T-segments [[Category: Un...

New page

'''Unreleased structure'''

The entry 8czq is ON HOLD

Authors: Tan, K., Tse-Dinh, Y.C.

Description: The crystal structure of MtbTOP1 in complex with both G-and T-segments
[[Category: Unreleased Structures]]
[[Category: Tse-Dinh, Y.C]]
[[Category: Tan, K]]