8d1t - Revision history

OCA at 10:05, 25 October 2023

OCA — Wed, 25 Oct 2023 10:05:59 GMT

←Older revision		Revision as of 10:05, 25 October 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8d1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[8d1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PXW:(1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3-(1-cyanocyclopropyl)[1,1-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium'>PXW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.94Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PXW:(1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3-(1-cyanocyclopropyl)[1,1-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium'>PXW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1t OCA], [https://pdbe.org/8d1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1t RCSB], [https://www.ebi.ac.uk/pdbsum/8d1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1t OCA], [https://pdbe.org/8d1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1t RCSB], [https://www.ebi.ac.uk/pdbsum/8d1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1t ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:21, 1 February 2023

OCA — Wed, 01 Feb 2023 11:21:04 GMT

←Older revision		Revision as of 11:21, 1 February 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8d1t ~~is ON HOLD~~	+	==Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab==
-		+	<StructureSection load='8d1t' size='340' side='right'caption='[[8d1t]], [[Resolution\|resolution]] 2.94Å' scene=''>
-	~~Authors~~: ~~Song, X~~., ~~Butler~~, J., Li, C., ~~Zhang~~, K., ~~Zhang~~, D., ~~Hao~~, Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8d1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1T FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of human USP30 in complex with~~ a ~~covalent~~ inhibitor ~~552~~ and ~~a Fab~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PXW:(1R,2R,4S,7E)-7-[amino(sulfanyl)methylidene]-2-{[(1P)-3-chloro-3-(1-cyanocyclopropyl)[1,1-biphenyl]-4-carbonyl]amino}-7-azabicyclo[2.2.1]heptan-7-ium'>PXW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1t OCA], [https://pdbe.org/8d1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1t RCSB], [https://www.ebi.ac.uk/pdbsum/8d1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1t ProSAT]</span></td></tr>
-	[[Category: ~~Butler, J~~]]	+	</table>
-	[[Category: ~~Li, C~~]]	+	== Function ==
-	[[Category: Hao, Y]]	+	[https://www.uniprot.org/uniprot/UBP30_HUMAN UBP30_HUMAN] Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).[UniProtKB:Q3UN04]<ref>PMID:18287522</ref> <ref>PMID:24896179</ref> <ref>PMID:25527291</ref> <ref>PMID:25621951</ref>
-	[[Category: Song, X]]	+	== References ==
-	[[Category: Zhang~~, K~~]]	+	<references/>
-	[[Category: Zhang~~, D~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Butler J]]
		+	[[Category: Hao Y]]
		+	[[Category: Li C]]
		+	[[Category: Song X]]
		+	[[Category: Zhang D]]
		+	[[Category: Zhang K]]

OCA at 07:25, 22 June 2022

OCA — Wed, 22 Jun 2022 07:25:17 GMT

←Older revision		Revision as of 07:25, 22 June 2022
Line 9:		Line 9:
	[[Category: Butler, J]]		[[Category: Butler, J]]
	[[Category: Li, C]]		[[Category: Li, C]]
-	[[Category: Zhang, D]]
	[[Category: Hao, Y]]		[[Category: Hao, Y]]
	[[Category: Song, X]]		[[Category: Song, X]]
	[[Category: Zhang, K]]		[[Category: Zhang, K]]
		+	[[Category: Zhang, D]]

OCA: Protected "8d1t" [edit=sysop:move=sysop]

OCA — Wed, 08 Jun 2022 04:32:48 GMT

Protected "8d1t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 8 June 2022

OCA: New page: '''Unreleased structure''' The entry 8d1t is ON HOLD Authors: Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y. Description: Crystal structure of human USP30 in complex with ...

OCA — Wed, 08 Jun 2022 04:32:47 GMT

New page: '''Unreleased structure''' The entry 8d1t is ON HOLD Authors: Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y. Description: Crystal structure of human USP30 in complex with ...

New page

'''Unreleased structure'''

The entry 8d1t is ON HOLD

Authors: Song, X., Butler, J., Li, C., Zhang, K., Zhang, D., Hao, Y.

Description: Crystal structure of human USP30 in complex with a covalent inhibitor 552 and a Fab
[[Category: Unreleased Structures]]
[[Category: Butler, J]]
[[Category: Li, C]]
[[Category: Zhang, D]]
[[Category: Hao, Y]]
[[Category: Song, X]]
[[Category: Zhang, K]]