8d7i - Revision history

OCA at 10:07, 25 October 2023

OCA — Wed, 25 Oct 2023 10:07:10 GMT

←Older revision		Revision as of 10:07, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8d7i]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D7I FirstGlance]. <br>		<table><tr><td colspan='2'>[[8d7i]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D7I FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d7i OCA], [https://pdbe.org/8d7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d7i RCSB], [https://www.ebi.ac.uk/pdbsum/8d7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d7i ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.63Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d7i OCA], [https://pdbe.org/8d7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d7i RCSB], [https://www.ebi.ac.uk/pdbsum/8d7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d7i ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 08:17, 14 June 2023

OCA — Wed, 14 Jun 2023 08:17:13 GMT

←Older revision		Revision as of 08:17, 14 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8d7i is ~~ON HOLD until Paper Publication~~	+	==Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap1 from S. aureus==
-		+	<StructureSection load='8d7i' size='340' side='right'caption='[[8d7i]], [[Resolution\|resolution]] 3.63Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8d7i]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D7I FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d7i OCA], [https://pdbe.org/8d7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d7i RCSB], [https://www.ebi.ac.uk/pdbsum/8d7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d7i ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[https://omim.org/entry/162800 162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[https://omim.org/entry/202700 202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
		+	[[Category: Geisbrecht BV]]
		+	[[Category: Gido CD]]
		+	[[Category: Herdendorf TJ]]

OCA at 04:21, 20 July 2022

OCA — Wed, 20 Jul 2022 04:21:31 GMT

←Older revision		Revision as of 04:21, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8d7i is ON HOLD	+	The entry 8d7i is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8d7i" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2022 04:13:56 GMT

Protected "8d7i" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:13, 15 June 2022

OCA: New page: '''Unreleased structure''' The entry 8d7i is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Jun 2022 04:13:55 GMT

New page: '''Unreleased structure''' The entry 8d7i is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8d7i is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]