OCA at 06:50, 29 March 2023

OCA — Wed, 29 Mar 2023 06:50:17 GMT

←Older revision		Revision as of 06:50, 29 March 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8d7r is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of human CLCF1 signaling complex: model containing the interaction core region==
		+	<StructureSection load='8d7r' size='340' side='right'caption='[[8d7r]], [[Resolution\|resolution]] 3.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8d7r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D7R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d7r OCA], [https://pdbe.org/8d7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d7r RCSB], [https://www.ebi.ac.uk/pdbsum/8d7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d7r ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo-electron microscopy structures of five signaling complexes of this family, containing full receptor ectodomains bound to their respective ligands ciliary neurotrophic factor, cardiotrophin-like cytokine factor 1 (CLCF1), leukemia inhibitory factor, IL-27, and IL-6. Our structures collectively reveal similarities and differences in the assembly of these complexes. The acute bends at both signaling receptors in all complexes bring the membrane-proximal domains to a ~30 angstrom range but with distinct distances and orientations. We also reveal how CLCF1 engages its secretion chaperone cytokine receptor-like factor 1. Our data provide valuable insights for therapeutically targeting gp130-mediated signaling.

-	~~Authors~~:	+	Structural insights into the assembly of gp130 family cytokine signaling complexes.,Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC Sci Adv. 2023 Mar 15;9(11):eade4395. doi: 10.1126/sciadv.ade4395. Epub 2023 Mar , 17. PMID:36930708<ref>PMID:36930708</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8d7r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Franklin MC]]
		+	[[Category: Zhou Y]]

OCA at 04:21, 20 July 2022

OCA — Wed, 20 Jul 2022 04:21:39 GMT

←Older revision		Revision as of 04:21, 20 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8d7r is ON HOLD	+	The entry 8d7r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8d7r" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2022 04:14:16 GMT

Protected "8d7r" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:14, 15 June 2022

OCA: New page: '''Unreleased structure''' The entry 8d7r is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Jun 2022 04:14:15 GMT

New page: '''Unreleased structure''' The entry 8d7r is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8d7r is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8d7r - Revision history

OCA at 06:50, 29 March 2023

OCA at 04:21, 20 July 2022

OCA: Protected "8d7r" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8d7r is ON HOLD Authors: Description: Category: Unreleased Structures