8dfg - Revision history

OCA at 17:27, 18 October 2023

OCA — Wed, 18 Oct 2023 17:27:57 GMT

←Older revision		Revision as of 17:27, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dfg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DFG FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dfg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DFG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dfg OCA], [https://pdbe.org/8dfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dfg RCSB], [https://www.ebi.ac.uk/pdbsum/8dfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dfg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dfg OCA], [https://pdbe.org/8dfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dfg RCSB], [https://www.ebi.ac.uk/pdbsum/8dfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dfg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 8dfg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 8dfg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:36, 19 October 2022

OCA — Wed, 19 Oct 2022 19:36:08 GMT

←Older revision		Revision as of 19:36, 19 October 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8dfg is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of potently neutralizing human monoclonal antibody 42D6 Fab in complex with MSP1-19==
		+	<StructureSection load='8dfg' size='340' side='right'caption='[[8dfg]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8dfg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DFG FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dfg OCA], [https://pdbe.org/8dfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dfg RCSB], [https://www.ebi.ac.uk/pdbsum/8dfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dfg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8I0U8_PLAF7 Q8I0U8_PLAF7]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Defining mechanisms of pathogen immune evasion and neutralization are critical to develop potent vaccines and therapies. Merozoite Surface Protein 1 (MSP-1) is a malaria vaccine antigen and antibodies to MSP-1 are associated with protection from disease. However, MSP-1-based vaccines performed poorly in clinical trials in part due to a limited understanding of the protective antibody response to MSP-1 and of immune evasion by antigenic diversion. Antigenic diversion was identified as a mechanism wherein parasite neutralization by a MSP-1-specific rodent antibody was disrupted by MSP-1-specific non-inhibitory blocking/interfering antibodies. Here, we investigated a panel of MSP-1-specific naturally acquired human monoclonal antibodies (hmAbs). Structures of multiple hmAbs with diverse neutralizing potential in complex with MSP-1 revealed the epitope of a potent strain-transcending hmAb. This neutralizing epitope overlaps with the epitopes of high-affinity non-neutralizing hmAbs. Strikingly, the non-neutralizing hmAbs outcompete the neutralizing hmAb enabling parasite survival. These findings demonstrate the structural and mechanistic basis for a generalizable pathogen immune evasion mechanism through neutralizing and interfering human antibodies elicited by antigenic diversion, and provides insights required to develop potent and durable malaria interventions.

-	~~Authors~~:	+	Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion.,Patel PN, Dickey TH, Hopp CS, Diouf A, Tang WK, Long CA, Miura K, Crompton PD, Tolia NH Nat Commun. 2022 Oct 6;13(1):5888. doi: 10.1038/s41467-022-33336-3. PMID:36202833<ref>PMID:36202833</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8dfg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Plasmodium falciparum 3D7]]
		+	[[Category: Patel PN]]
		+	[[Category: Tang WK]]
		+	[[Category: Tolia NH]]

OCA at 16:42, 27 July 2022

OCA — Wed, 27 Jul 2022 16:42:06 GMT

←Older revision		Revision as of 16:42, 27 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dfg is ON HOLD	+	The entry 8dfg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dfg" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2022 06:32:54 GMT

Protected "8dfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:32, 29 June 2022

OCA: New page: '''Unreleased structure''' The entry 8dfg is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Jun 2022 06:32:53 GMT

New page: '''Unreleased structure''' The entry 8dfg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dfg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]