8dhz - Revision history

OCA at 19:02, 7 September 2022

OCA — Wed, 07 Sep 2022 19:02:42 GMT

←Older revision		Revision as of 19:02, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GALA_HUMAN GALA_HUMAN]] Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.<ref>PMID:1370155</ref> <ref>PMID:1722333</ref> <ref>PMID:25691535</ref>		[[https://www.uniprot.org/uniprot/GALA_HUMAN GALA_HUMAN]] Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.<ref>PMID:1370155</ref> <ref>PMID:1722333</ref> <ref>PMID:25691535</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human galanin is a 30-residue neuropeptide targeted for development of analgesics, antidepressants, and anticonvulsants. While previous work from our group and others has already produced significant insights into galanin's N-terminal region, no extant structures of galanin in databases include its full-length sequence and the function of its C-terminus remains ambiguous. We report the NMR solution structure of full-length human galanin C-terminal amide, determined from 2D (1)H-(1)H COSY, TOCSY, and ROESY NMR data. Galanin adopts an irregular helical structure across its N-terminus, likely the average of several coiling states. We present the NMR structure of a peptide encompassing the C-terminus of galanin as a stand-alone fragment. The C-terminus of full-length galanin appears to indirectly assist the intramolecular association of hydrophobic sidechains within its N-terminus, remotely rigidifying their position when compared to previously studied N-terminal galanin fragments. By contrast, there is flexibility in the C-terminus of galanin, characterized by two i to i + 2 hydrogen-bonded turns within an otherwise dynamic backbone. The C-terminal portion of the peptide renders it soluble, and plays a hitherto undescribed biophysical role in pre-organizing the galanin receptor binding epitope. We speculate that hydrophilic microdomains of signaling peptides, hormones, and perhaps intrinsically disordered proteins may also function similarly.
		+
		+	The neuropeptide galanin adopts an irregular secondary structure.,Wilkinson RE, Kraichely KN, Hendy CM, Buchanan LE, Parnham S, Giuliano MW Biochem Biophys Res Commun. 2022 Oct 20;626:121-128. doi:, 10.1016/j.bbrc.2022.08.032. Epub 2022 Aug 15. PMID:35994823<ref>PMID:35994823</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8dhz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:51, 7 September 2022

OCA — Wed, 07 Sep 2022 16:51:53 GMT

←Older revision		Revision as of 16:51, 7 September 2022
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	<StructureSection load='8dhz' size='340' side='right'caption='[[8dhz]]' scene=''>		<StructureSection load='8dhz' size='340' side='right'caption='[[8dhz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8dhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DHZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dhz OCA], [https://pdbe.org/8dhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dhz RCSB], [https://www.ebi.ac.uk/pdbsum/8dhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dhz ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dhz OCA], [https://pdbe.org/8dhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dhz RCSB], [https://www.ebi.ac.uk/pdbsum/8dhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dhz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/GALA_HUMAN GALA_HUMAN]] The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GALA_HUMAN GALA_HUMAN]] Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.<ref>PMID:1370155</ref> <ref>PMID:1722333</ref> <ref>PMID:25691535</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Giuliano MW]]		[[Category: Giuliano MW]]

OCA at 04:52, 25 August 2022

OCA — Thu, 25 Aug 2022 04:52:44 GMT

←Older revision		Revision as of 04:52, 25 August 2022
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-	'''Unreleased structure'''

-	~~The entry 8dhz is ON HOLD until Paper Publication~~	+	==NMR Structure of Ac-hGal(17-30)NH2, an N-terminally acetylated fragment of the C-terminus of human galanin==
-		+	<StructureSection load='8dhz' size='340' side='right'caption='[[8dhz]]' scene=''>
-	~~Authors: Kraichely, K.N., Hendy, C.M., Parnham, S., Giuliano, M.W.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DHZ FirstGlance]. <br>
-	~~Description:~~ NMR Structure of Ac-hGal(17-30)NH2, an N-terminally acetylated fragment of the C-terminus of human galanin	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dhz OCA], [https://pdbe.org/8dhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dhz RCSB], [https://www.ebi.ac.uk/pdbsum/8dhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dhz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Hendy, C.M~~]]	+	__TOC__
-	[[Category: ~~Parnham, S~~]]	+	</StructureSection>
-	[[Category: Kraichely~~, K.N~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Giuliano, M.W~~]]	+	[[Category: Giuliano MW]]
		+	[[Category: Hendy CM]]
		+	[[Category: Kraichely KN]]
		+	[[Category: Parnham S]]

OCA: Protected "8dhz" [edit=sysop:move=sysop]

OCA — Wed, 06 Jul 2022 15:14:23 GMT

Protected "8dhz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:14, 6 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dhz is ON HOLD until Paper Publication Authors: Kraichely, K.N., Hendy, C.M., Parnham, S., Giuliano, M.W. Description: NMR Structure of Ac-hGal(17...

OCA — Wed, 06 Jul 2022 15:14:22 GMT

New page: '''Unreleased structure''' The entry 8dhz is ON HOLD until Paper Publication Authors: Kraichely, K.N., Hendy, C.M., Parnham, S., Giuliano, M.W. Description: NMR Structure of Ac-hGal(17...

New page

'''Unreleased structure'''

The entry 8dhz is ON HOLD until Paper Publication

Authors: Kraichely, K.N., Hendy, C.M., Parnham, S., Giuliano, M.W.

Description: NMR Structure of Ac-hGal(17-30)NH2, an N-terminally acetylated fragment of the C-terminus of human galanin
[[Category: Unreleased Structures]]
[[Category: Hendy, C.M]]
[[Category: Parnham, S]]
[[Category: Kraichely, K.N]]
[[Category: Giuliano, M.W]]