OCA at 03:27, 8 September 2022

OCA — Thu, 08 Sep 2022 03:27:25 GMT

←Older revision		Revision as of 03:27, 8 September 2022
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-	====	+	==HMGCR-UBIAD1 Complex State 1==
-	<StructureSection load='8djm' size='340' side='right'caption='[[8djm]]' scene=''>	+	<StructureSection load='8djm' size='340' side='right'caption='[[8djm]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[8djm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DJM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8djm OCA], [https://pdbe.org/8djm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8djm RCSB], [https://www.ebi.ac.uk/pdbsum/8djm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8djm ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AJP:Digitonin'>AJP</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8djm OCA], [https://pdbe.org/8djm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8djm RCSB], [https://www.ebi.ac.uk/pdbsum/8djm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8djm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HMDH_CRIGR HMDH_CRIGR]] Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis.[UniProtKB:P04035]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols in endoplasmic reticulum (ER) membranes accelerates degradation of HMGCR, slowing the synthesis of cholesterol. Degradation of HMGCR is inhibited by its binding to UBIAD1 (UbiA prenyltransferase domain-containing protein-1). This inhibition contributes to statin-induced accumulation of HMGCR, which limits their cholesterol-lowering effects. Here, we report cryo-electron microscopy structures of the HMGCR-UBIAD1 complex, which is maintained by interactions between transmembrane helix (TM) 7 of HMGCR and TMs 2-4 of UBIAD1. Disrupting this interface by mutagenesis prevents complex formation, enhancing HMGCR degradation. TMs 2-6 of HMGCR contain a 170-amino acid sterol sensing domain (SSD), which exists in two conformations-one of which is essential for degradation. Thus, our data supports a model that rearrangement of the TMs in the SSD permits recruitment of proteins that initate HMGCR degradation, a key reaction in the regulatory system that governs cholesterol synthesis.
		+
		+	Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.,Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X Nat Commun. 2022 Jul 25;13(1):4273. doi: 10.1038/s41467-022-32025-5. PMID:35879350<ref>PMID:35879350</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 8djm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cricetulus griseus]]
		+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Chen H]]
		+	[[Category: Li X]]
		+	[[Category: Qi X]]

OCA at 04:56, 3 August 2022

OCA — Wed, 03 Aug 2022 04:56:17 GMT

←Older revision		Revision as of 04:56, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8djm ~~is ON HOLD~~	+	====
-		+	<StructureSection load='8djm' size='340' side='right'caption='[[8djm]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8djm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8djm OCA], [https://pdbe.org/8djm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8djm RCSB], [https://www.ebi.ac.uk/pdbsum/8djm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8djm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "8djm" [edit=sysop:move=sysop]

OCA — Wed, 06 Jul 2022 15:17:26 GMT

Protected "8djm" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:17, 6 July 2022

OCA: New page: '''Unreleased structure''' The entry 8djm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Jul 2022 15:17:25 GMT

New page: '''Unreleased structure''' The entry 8djm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8djm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8djm - Revision history

OCA at 03:27, 8 September 2022

OCA at 04:56, 3 August 2022

OCA: Protected "8djm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8djm is ON HOLD Authors: Description: Category: Unreleased Structures