OCA at 20:31, 12 April 2023

OCA — Wed, 12 Apr 2023 20:31:44 GMT

←Older revision		Revision as of 20:31, 12 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8dnf is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Cryo-EM structure of nonmuscle gamma-actin==
		+	<StructureSection load='8dnf' size='340' side='right'caption='[[8dnf]], [[Resolution\|resolution]] 3.38Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8dnf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DNF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnf OCA], [https://pdbe.org/8dnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnf RCSB], [https://www.ebi.ac.uk/pdbsum/8dnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnf ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/ACTG_HUMAN ACTG_HUMAN] Baraitser-Winter syndrome;Autosomal dominant non-syndromic sensorineural deafness type DFNA. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ACTG_HUMAN ACTG_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Actin isoforms organize into distinct networks that are essential for the normal function of eukaryotic cells. Despite a high level of sequence and structure conservation, subtle differences in their design principles determine the interaction with myosin motors and actin-binding proteins. Therefore, identifying how the structure of actin isoforms relates to function is important for our understanding of normal cytoskeletal physiology. Here, we report the high-resolution structures of filamentous skeletal muscle alpha-actin (3.37 A), cardiac muscle alpha-actin (3.07 A), ss-actin (2.99 A), and gamma-actin (3.38 A) in the Mg(2+).ADP state with their native post-translational modifications. The structures revealed isoform-specific conformations of the N-terminus that shift closer to the filament surface upon myosin binding, thereby establishing isoform-specific interfaces. Collectively, the structures of single-isotype, post-translationally modified bare skeletal muscle alpha-actin, cardiac muscle alpha-actin, ss-actin, and gamma-actin reveal general principles, similarities, and differences between isoforms. They complement the repertoire of known actin structures and allow for a comprehensive understanding of in vitro and in vivo functions of actin isoforms.

-	~~Authors: Arora, A.S~~., Huang, ~~H.L.~~, Heissler, ~~S.M.~~, Chinthalapudi, K.	+	Structural insights into actin isoforms.,Arora AS, Huang HL, Singh R, Narui Y, Suchenko A, Hatano T, Heissler SM, Balasubramanian MK, Chinthalapudi K Elife. 2023 Feb 15;12:e82015. doi: 10.7554/eLife.82015. PMID:36790143<ref>PMID:36790143</ref>

-	~~Description: Cryo-EM structure~~ of ~~nonmuscle gamma~~-~~actin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Heissler, S.M~~]]	+	<div class="pdbe-citations 8dnf" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Huang, H.L~~]]	+	== References ==
-	[[Category: Chinthalapudi, K]]	+	<references/>
-	[[Category: ~~Arora, A.S~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Arora AS]]
		+	[[Category: Chinthalapudi K]]
		+	[[Category: Heissler SM]]
		+	[[Category: Huang HL]]

OCA at 16:43, 27 July 2022

OCA — Wed, 27 Jul 2022 16:43:31 GMT

←Older revision		Revision as of 16:43, 27 July 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dnf is ON HOLD	+	The entry 8dnf is ON HOLD until Paper Publication

	Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K.		Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K.

OCA: Protected "8dnf" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:32:00 GMT

Protected "8dnf" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:32, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dnf is ON HOLD Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K. Description: Cryo-EM structure of nonmuscle gamma-actin [[Cate...

OCA — Wed, 20 Jul 2022 04:31:58 GMT

New page: '''Unreleased structure''' The entry 8dnf is ON HOLD Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K. Description: Cryo-EM structure of nonmuscle gamma-actin [[Cate...

New page

'''Unreleased structure'''

The entry 8dnf is ON HOLD

Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K.

Description: Cryo-EM structure of nonmuscle gamma-actin
[[Category: Unreleased Structures]]
[[Category: Heissler, S.M]]
[[Category: Huang, H.L]]
[[Category: Chinthalapudi, K]]
[[Category: Arora, A.S]]

8dnf - Revision history

OCA at 20:31, 12 April 2023

OCA at 16:43, 27 July 2022

OCA: Protected "8dnf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dnf is ON HOLD Authors: Arora, A.S., Huang, H.L., Heissler, S.M., Chinthalapudi, K. Description: Cryo-EM structure of nonmuscle gamma-actin [[Cate...