OCA at 06:12, 19 July 2023

OCA — Wed, 19 Jul 2023 06:12:22 GMT

←Older revision		Revision as of 06:12, 19 July 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8dnr is ~~ON HOLD until Paper Publication~~	+	==Prefusion-stabilized Hendra virus fusion protein==
-		+	<StructureSection load='8dnr' size='340' side='right'caption='[[8dnr]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dnr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_henipavirus Hendra henipavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DNR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnr OCA], [https://pdbe.org/8dnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnr RCSB], [https://www.ebi.ac.uk/pdbsum/8dnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FUS_HENDH FUS_HENDH] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hendra henipavirus]]
		+	[[Category: Large Structures]]
		+	[[Category: Blade EG]]
		+	[[Category: Byrne PO]]
		+	[[Category: McLellan JS]]

OCA at 03:47, 25 August 2022

OCA — Thu, 25 Aug 2022 03:47:51 GMT

←Older revision		Revision as of 03:47, 25 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dnr is ON HOLD	+	The entry 8dnr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dnr" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:33:06 GMT

Protected "8dnr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:33, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dnr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jul 2022 04:33:04 GMT

New page: '''Unreleased structure''' The entry 8dnr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dnr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8dnr - Revision history

OCA at 06:12, 19 July 2023

OCA at 03:47, 25 August 2022

OCA: Protected "8dnr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dnr is ON HOLD Authors: Description: Category: Unreleased Structures