8dnv - Revision history

OCA at 10:09, 6 September 2023

OCA — Wed, 06 Sep 2023 10:09:07 GMT

←Older revision		Revision as of 10:09, 6 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8dnv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DNV FirstGlance]. <br>		<table><tr><td colspan='2'>[[8dnv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DNV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnv OCA], [https://pdbe.org/8dnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnv RCSB], [https://www.ebi.ac.uk/pdbsum/8dnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.03Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnv OCA], [https://pdbe.org/8dnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnv RCSB], [https://www.ebi.ac.uk/pdbsum/8dnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:04, 25 May 2023

OCA — Thu, 25 May 2023 04:04:01 GMT

←Older revision		Revision as of 04:04, 25 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8dnv is ~~ON HOLD until Paper~~ Publication	+	==Cryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 1)==
		+	<StructureSection load='8dnv' size='340' side='right'caption='[[8dnv]], [[Resolution\|resolution]] 3.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8dnv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DNV FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dnv OCA], [https://pdbe.org/8dnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dnv RCSB], [https://www.ebi.ac.uk/pdbsum/8dnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dnv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SC61G_HUMAN SC61G_HUMAN] Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).[UniProtKB:P60058][UniProtKB:P61619]<ref>PMID:32820719</ref> <ref>PMID:36261522</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum membrane that is required for secretion of soluble proteins and production of many membrane proteins. Several natural and synthetic small molecules specifically inhibit Sec61, generating cellular effects that are useful for therapeutic purposes, but their inhibitory mechanisms remain unclear. Here we present near-atomic-resolution structures of human Sec61 inhibited by a comprehensive panel of structurally distinct small molecules-cotransin, decatransin, apratoxin, ipomoeassin, mycolactone, cyclotriazadisulfonamide and eeyarestatin. All inhibitors bind to a common lipid-exposed pocket formed by the partially open lateral gate and plug domain of Sec61. Mutations conferring resistance to the inhibitors are clustered at this binding pocket. The structures indicate that Sec61 inhibitors stabilize the plug domain in a closed state, thereby preventing the protein-translocation pore from opening. Our study provides the atomic details of Sec61-inhibitor interactions and the structural framework for further pharmacological studies and drug design.

-	~~Authors~~:	+	A common mechanism of Sec61 translocon inhibition by small molecules.,Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, Shi WQ, Forsyth C, Hoepfner D, Spiess M, Park E Nat Chem Biol. 2023 May 11. doi: 10.1038/s41589-023-01337-y. PMID:37169959<ref>PMID:37169959</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8dnv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Itskanov S]]
		+	[[Category: Park E]]

OCA at 04:03, 18 August 2022

OCA — Thu, 18 Aug 2022 04:03:00 GMT

←Older revision		Revision as of 04:03, 18 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dnv is ON HOLD	+	The entry 8dnv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dnv" [edit=sysop:move=sysop]

OCA — Wed, 20 Jul 2022 04:33:31 GMT

Protected "8dnv" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:33, 20 July 2022

OCA: New page: '''Unreleased structure''' The entry 8dnv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Jul 2022 04:33:29 GMT

New page: '''Unreleased structure''' The entry 8dnv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dnv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]