8drq - Revision history

OCA at 05:53, 5 July 2023

OCA — Wed, 05 Jul 2023 05:53:44 GMT

←Older revision		Revision as of 05:53, 5 July 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8drq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[8drq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drq OCA], [https://pdbe.org/8drq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drq RCSB], [https://www.ebi.ac.uk/pdbsum/8drq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.16Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drq OCA], [https://pdbe.org/8drq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drq RCSB], [https://www.ebi.ac.uk/pdbsum/8drq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.		[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:34, 8 March 2023

OCA — Wed, 08 Mar 2023 07:34:53 GMT

←Older revision		Revision as of 07:34, 8 March 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8drq ~~is ON HOLD until Paper Publication~~	+	==LRRC8A:C conformation 1 (round) LRR focus 3==
-		+	<StructureSection load='8drq' size='340' side='right'caption='[[8drq]], [[Resolution\|resolution]] 4.16Å' scene=''>
-	~~Authors~~: ~~Kern~~, D.M., ~~Brohawn~~, S.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8drq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DRQ FirstGlance]. <br>
-	~~Description~~: ~~LRRC8A~~:~~C conformation 1~~ (~~round~~) ~~LRR focus 3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8drq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drq OCA], [https://pdbe.org/8drq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8drq RCSB], [https://www.ebi.ac.uk/pdbsum/8drq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8drq ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Brohawn~~, S.G~~]]	+	== Function ==
-	[[Category: Kern~~, D.M~~]]	+	[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Brohawn SG]]
		+	[[Category: Kern DM]]

OCA at 03:48, 25 August 2022

OCA — Thu, 25 Aug 2022 03:48:59 GMT

←Older revision		Revision as of 03:48, 25 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8drq is ON HOLD	+	The entry 8drq is ON HOLD until Paper Publication

	Authors: Kern, D.M., Brohawn, S.G.		Authors: Kern, D.M., Brohawn, S.G.

OCA: Protected "8drq" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2022 16:48:42 GMT

Protected "8drq" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:48, 27 July 2022

OCA: New page: '''Unreleased structure''' The entry 8drq is ON HOLD Authors: Kern, D.M., Brohawn, S.G. Description: LRRC8A:C conformation 1 (round) LRR focus 3 Category: Unreleased Structures [[C...

OCA — Wed, 27 Jul 2022 16:48:40 GMT

New page: '''Unreleased structure''' The entry 8drq is ON HOLD Authors: Kern, D.M., Brohawn, S.G. Description: LRRC8A:C conformation 1 (round) LRR focus 3 Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 8drq is ON HOLD

Authors: Kern, D.M., Brohawn, S.G.

Description: LRRC8A:C conformation 1 (round) LRR focus 3
[[Category: Unreleased Structures]]
[[Category: Brohawn, S.G]]
[[Category: Kern, D.M]]