OCA at 06:55, 27 September 2023

OCA — Wed, 27 Sep 2023 06:55:17 GMT

←Older revision		Revision as of 06:55, 27 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8dsw is ~~ON HOLD~~	+	==Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant==
-		+	<StructureSection load='8dsw' size='340' side='right'caption='[[8dsw]], [[Resolution\|resolution]] 2.39Å' scene=''>
-	~~Authors~~: ~~Park~~, E., ~~Eck~~, M.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSW FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of~~ EGFR kinase ~~domain~~, ~~Exon20 Insertion FQEA mutant~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	[[Category: Eck~~, M.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsw OCA], [https://pdbe.org/8dsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsw RCSB], [https://www.ebi.ac.uk/pdbsum/8dsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsw ProSAT]</span></td></tr>
-	[[Category: Park, E]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Defects in EGFR are associated with lung cancer (LNCR) [MIM:[https://omim.org/entry/211980 211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EGFR_HUMAN EGFR_HUMAN] Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref> Isoform 2 may act as an antagonist of EGF action.<ref>PMID:7657591</ref> <ref>PMID:11602604</ref> <ref>PMID:12873986</ref> <ref>PMID:10805725</ref> <ref>PMID:11116146</ref> <ref>PMID:11483589</ref> <ref>PMID:17115032</ref> <ref>PMID:21258366</ref> <ref>PMID:12297050</ref> <ref>PMID:12620237</ref> <ref>PMID:15374980</ref> <ref>PMID:19560417</ref> <ref>PMID:20837704</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Eck MJ]]
		+	[[Category: Park E]]

OCA: Protected "8dsw" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2022 03:55:44 GMT

Protected "8dsw" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 3 August 2022

OCA: New page: '''Unreleased structure''' The entry 8dsw is ON HOLD Authors: Park, E., Eck, M.J. Description: Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant [[Category: Unrelea...

OCA — Wed, 03 Aug 2022 03:55:43 GMT

New page: '''Unreleased structure''' The entry 8dsw is ON HOLD Authors: Park, E., Eck, M.J. Description: Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 8dsw is ON HOLD

Authors: Park, E., Eck, M.J.

Description: Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
[[Category: Unreleased Structures]]
[[Category: Eck, M.J]]
[[Category: Park, E]]

8dsw - Revision history

OCA at 06:55, 27 September 2023

OCA: Protected "8dsw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dsw is ON HOLD Authors: Park, E., Eck, M.J. Description: Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant [[Category: Unrelea...