OCA at 16:42, 7 September 2022

OCA — Wed, 07 Sep 2022 16:42:24 GMT

←Older revision		Revision as of 16:42, 7 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8dtm ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of insulin receptor (IR) bound with S597 component 2==
-		+	<StructureSection load='8dtm' size='340' side='right'caption='[[8dtm]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dtm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DTM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dtm OCA], [https://pdbe.org/8dtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dtm RCSB], [https://www.ebi.ac.uk/pdbsum/8dtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dtm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/INSR_MOUSE INSR_MOUSE]] Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). When present in a hybrid receptor with IGF1R, binds IGF1 (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Accili D]]
		+	[[Category: Bai XC]]
		+	[[Category: Ball KA]]
		+	[[Category: Choi E]]
		+	[[Category: Hall C]]
		+	[[Category: Li J]]
		+	[[Category: Mayer JP]]
		+	[[Category: Park J]]
		+	[[Category: Stowell MHB]]
		+	[[Category: Wu JY]]

OCA at 03:49, 25 August 2022

OCA — Thu, 25 Aug 2022 03:49:23 GMT

←Older revision		Revision as of 03:49, 25 August 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dtm is ON HOLD	+	The entry 8dtm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dtm" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2022 03:56:47 GMT

Protected "8dtm" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 3 August 2022

OCA: New page: '''Unreleased structure''' The entry 8dtm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Aug 2022 03:56:46 GMT

New page: '''Unreleased structure''' The entry 8dtm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dtm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8dtm - Revision history

OCA at 16:42, 7 September 2022

OCA at 03:49, 25 August 2022

OCA: Protected "8dtm" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dtm is ON HOLD Authors: Description: Category: Unreleased Structures