OCA at 07:30, 3 May 2023

OCA — Wed, 03 May 2023 07:30:13 GMT

←Older revision		Revision as of 07:30, 3 May 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8dzr is ~~ON HOLD until Paper Publication~~	+	==GR89,696 bound Kappa Opioid Receptor in complex with Ggustducin==
-		+	<StructureSection load='8dzr' size='340' side='right'caption='[[8dzr]], [[Resolution\|resolution]] 2.61Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8dzr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DZR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U9I:methyl+(3R)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate'>U9I</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dzr OCA], [https://pdbe.org/8dzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dzr RCSB], [https://www.ebi.ac.uk/pdbsum/8dzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dzr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Che T]]
		+	[[Category: Fay JF]]

OCA at 04:23, 2 March 2023

OCA — Thu, 02 Mar 2023 04:23:55 GMT

←Older revision		Revision as of 04:23, 2 March 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8dzr is ON HOLD	+	The entry 8dzr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8dzr" [edit=sysop:move=sysop]

OCA — Thu, 18 Aug 2022 04:08:20 GMT

Protected "8dzr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 18 August 2022

OCA: New page: '''Unreleased structure''' The entry 8dzr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 18 Aug 2022 04:08:19 GMT

New page: '''Unreleased structure''' The entry 8dzr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8dzr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8dzr - Revision history

OCA at 07:30, 3 May 2023

OCA at 04:23, 2 March 2023

OCA: Protected "8dzr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8dzr is ON HOLD Authors: Description: Category: Unreleased Structures