OCA at 21:17, 28 June 2023

OCA — Wed, 28 Jun 2023 21:17:15 GMT

←Older revision		Revision as of 21:17, 28 June 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8e3m ~~is ON HOLD until Paper Publication~~	+	==E. coli 50S ribosome bound to L-linker solithromycin conjugate==
-		+	<StructureSection load='8e3m' size='340' side='right'caption='[[8e3m]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~Authors~~: ~~Pellegrino~~, J., ~~Lee~~, D.J., ~~Fraser~~, J.S., ~~Seiple~~, I.B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8e3m]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E3M FirstGlance]. <br>
-	~~Description~~: E. coli ~~50S~~ ribosome ~~bound~~ to L-~~linker solithromycin conjugate~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UIU:N-acetyl-L-tyrosyl-N-[(3M)-3-(1-{4-[(3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}dodecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-1(4H)-yl]butyl}-1H-1,2,3-triazol-4-yl)phenyl]-L-methioninamide'>UIU</scene></td></tr>
-	[[Category: ~~Seiple, I.B~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e3m OCA], [https://pdbe.org/8e3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e3m RCSB], [https://www.ebi.ac.uk/pdbsum/8e3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e3m ProSAT]</span></td></tr>
-	[[Category: ~~Lee, D.J~~]]	+	</table>
-	[[Category: Fraser~~, J.S~~]]	+	== Function ==
-	[[Category: Pellegrino, J]]	+	[https://www.uniprot.org/uniprot/RL2_ECOLI RL2_ECOLI] One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial.[HAMAP-Rule:MF_01320_B] In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.[HAMAP-Rule:MF_01320_B]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Large Structures]]
		+	[[Category: Fraser JS]]
		+	[[Category: Lee DJ]]
		+	[[Category: Pellegrino J]]
		+	[[Category: Seiple IB]]

OCA at 15:32, 7 September 2022

OCA — Wed, 07 Sep 2022 15:32:28 GMT

←Older revision		Revision as of 15:32, 7 September 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8e3m is ON HOLD	+	The entry 8e3m is ON HOLD until Paper Publication

	Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.		Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.
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	Description: E. coli 50S ribosome bound to L-linker solithromycin conjugate		Description: E. coli 50S ribosome bound to L-linker solithromycin conjugate
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Fraser, J.S]]
-	[[Category: Pellegrino, J]]
	[[Category: Seiple, I.B]]		[[Category: Seiple, I.B]]
	[[Category: Lee, D.J]]		[[Category: Lee, D.J]]
		+	[[Category: Fraser, J.S]]
		+	[[Category: Pellegrino, J]]

OCA: Protected "8e3m" [edit=sysop:move=sysop]

OCA — Thu, 25 Aug 2022 03:53:09 GMT

Protected "8e3m" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 8e3m is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to L-linker solithromycin co...

OCA — Thu, 25 Aug 2022 03:53:08 GMT

New page: '''Unreleased structure''' The entry 8e3m is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to L-linker solithromycin co...

New page

'''Unreleased structure'''

The entry 8e3m is ON HOLD

Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.

Description: E. coli 50S ribosome bound to L-linker solithromycin conjugate
[[Category: Unreleased Structures]]
[[Category: Fraser, J.S]]
[[Category: Pellegrino, J]]
[[Category: Seiple, I.B]]
[[Category: Lee, D.J]]

8e3m - Revision history

OCA at 21:17, 28 June 2023

OCA at 15:32, 7 September 2022

OCA: Protected "8e3m" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8e3m is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to L-linker solithromycin co...