8e41 - Revision history

OCA at 11:32, 15 November 2023

OCA — Wed, 15 Nov 2023 11:32:43 GMT

←Older revision		Revision as of 11:32, 15 November 2023
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RL2_ECOLI RL2_ECOLI] One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial.[HAMAP-Rule:MF_01320_B] In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.[HAMAP-Rule:MF_01320_B]		[https://www.uniprot.org/uniprot/RL2_ECOLI RL2_ECOLI] One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial.[HAMAP-Rule:MF_01320_B] In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.[HAMAP-Rule:MF_01320_B]
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:17, 28 June 2023

OCA — Wed, 28 Jun 2023 21:17:16 GMT

←Older revision		Revision as of 21:17, 28 June 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8e41 ~~is ON HOLD until Paper Publication~~	+	==E. coli 50S ribosome bound to tiamulin and VS1==
-		+	<StructureSection load='8e41' size='340' side='right'caption='[[8e41]], [[Resolution\|resolution]] 2.13Å' scene=''>
-	~~Authors~~: ~~Pellegrino~~, J., ~~Lee~~, D.J., ~~Fraser~~, J.S., ~~Seiple~~, I.B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8e41]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Streptomyces_virginiae Streptomyces virginiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E41 FirstGlance]. <br>
-	~~Description~~: E. coli ~~50S~~ ribosome ~~bound~~ to ~~tiamulin and VS1~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.13Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=004:(2S)-AMINO(PHENYL)ETHANOIC+ACID'>004</scene>, <scene name='pdbligand=1MG:1N-METHYLGUANOSINE-5-MONOPHOSPHATE'>1MG</scene>, <scene name='pdbligand=2MA:2-METHYLADENOSINE-5-MONOPHOSPHATE'>2MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=3TD:(1S)-1,4-ANHYDRO-1-(3-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)-5-O-PHOSPHONO-D-RIBITOL'>3TD</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=6MZ:N6-METHYLADENOSINE-5-MONOPHOSPHATE'>6MZ</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene>, <scene name='pdbligand=MHV:4-OXO-L-PIPECOLIC+ACID'>MHV</scene>, <scene name='pdbligand=MHW:3-HYDROXYPICOLINIC+ACID'>MHW</scene>, <scene name='pdbligand=MUL:TIAMULIN'>MUL</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
-	[[Category: ~~Fraser, J.S~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e41 OCA], [https://pdbe.org/8e41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e41 RCSB], [https://www.ebi.ac.uk/pdbsum/8e41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e41 ProSAT]</span></td></tr>
-	[[Category: ~~Pellegrino, J~~]]	+	</table>
-	[[Category: ~~Seiple, I.B~~]]	+	== Function ==
-	[[Category: Lee~~, D.~~J]]	+	[https://www.uniprot.org/uniprot/RL2_ECOLI RL2_ECOLI] One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial.[HAMAP-Rule:MF_01320_B] In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.[HAMAP-Rule:MF_01320_B]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
		+	[[Category: Streptomyces virginiae]]
		+	[[Category: Fraser JS]]
		+	[[Category: Lee DJ]]
		+	[[Category: Pellegrino J]]
		+	[[Category: Seiple IB]]

OCA at 05:33, 31 August 2022

OCA — Wed, 31 Aug 2022 05:33:52 GMT

←Older revision		Revision as of 05:33, 31 August 2022
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8e41 is ON HOLD	+	The entry 8e41 is ON HOLD until Paper Publication

	Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.		Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.

OCA: Protected "8e41" [edit=sysop:move=sysop]

OCA — Thu, 25 Aug 2022 03:53:45 GMT

Protected "8e41" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 25 August 2022

OCA: New page: '''Unreleased structure''' The entry 8e41 is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to tiamulin and VS1 [[Catego...

OCA — Thu, 25 Aug 2022 03:53:44 GMT

New page: '''Unreleased structure''' The entry 8e41 is ON HOLD Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B. Description: E. coli 50S ribosome bound to tiamulin and VS1 [[Catego...

New page

'''Unreleased structure'''

The entry 8e41 is ON HOLD

Authors: Pellegrino, J., Lee, D.J., Fraser, J.S., Seiple, I.B.

Description: E. coli 50S ribosome bound to tiamulin and VS1
[[Category: Unreleased Structures]]
[[Category: Fraser, J.S]]
[[Category: Pellegrino, J]]
[[Category: Seiple, I.B]]
[[Category: Lee, D.J]]