8edj - Revision history

OCA at 10:15, 16 August 2023

OCA — Wed, 16 Aug 2023 10:15:48 GMT

←Older revision		Revision as of 10:15, 16 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8edj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[8edj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edj OCA], [https://pdbe.org/8edj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edj RCSB], [https://www.ebi.ac.uk/pdbsum/8edj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edj OCA], [https://pdbe.org/8edj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edj RCSB], [https://www.ebi.ac.uk/pdbsum/8edj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 11 January 2023

OCA — Wed, 11 Jan 2023 07:42:38 GMT

←Older revision		Revision as of 07:42, 11 January 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8edj is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of rA3G-ssRNA-GA==
		+	<StructureSection load='8edj' size='340' side='right'caption='[[8edj]], [[Resolution\|resolution]] 1.83Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8edj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edj OCA], [https://pdbe.org/8edj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edj RCSB], [https://www.ebi.ac.uk/pdbsum/8edj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M1GSK9_MACMU M1GSK9_MACMU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An essential step in restricting HIV infectivity by the antiviral factor APOBEC3G is its incorporation into progeny virions via binding to HIV RNA. However, the mechanism of APOBEC3G capturing viral RNA is unknown. Here, we report crystal structures of a primate APOBEC3G bound to different types of RNAs, revealing that APOBEC3G specifically recognizes unpaired 5'-AA-3' dinucleotides, and to a lesser extent, 5'-GA-3' dinucleotides. APOBEC3G binds to the common 3'A in the AA/GA motifs using an aromatic/hydrophobic pocket in the non-catalytic domain. It binds to the 5'A or 5'G in the AA/GA motifs using an aromatic/hydrophobic groove conformed between the non-catalytic and catalytic domains. APOBEC3G RNA binding property is distinct from that of the HIV nucleocapsid protein recognizing unpaired guanosines. Our findings suggest that the sequence-specific RNA recognition is critical for APOBEC3G virion packaging and restricting HIV infectivity.

-	~~Authors~~:	+	Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.,Yang H, Kim K, Li S, Pacheco J, Chen XS Nat Commun. 2022 Dec 5;13(1):7498. doi: 10.1038/s41467-022-35201-9. PMID:36470880<ref>PMID:36470880</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8edj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Macaca mulatta]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Chen XJ]]
		+	[[Category: Li S-X]]
		+	[[Category: Pacheco J]]
		+	[[Category: Yang HJ]]

OCA at 08:31, 30 November 2022

OCA — Wed, 30 Nov 2022 08:31:54 GMT

←Older revision		Revision as of 08:31, 30 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8edj is ON HOLD	+	The entry 8edj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 03:57, 26 October 2022

OCA — Wed, 26 Oct 2022 03:57:54 GMT

←Older revision		Revision as of 03:57, 26 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8edj is ON HOLD ~~until Paper Publication~~	+	The entry 8edj is ON HOLD

	Authors:		Authors:

OCA at 17:09, 19 October 2022

OCA — Wed, 19 Oct 2022 17:09:19 GMT

←Older revision		Revision as of 17:09, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8edj is ON HOLD	+	The entry 8edj is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8edj" [edit=sysop:move=sysop]

OCA — Wed, 14 Sep 2022 05:48:52 GMT

Protected "8edj" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:48, 14 September 2022

OCA: New page: '''Unreleased structure''' The entry 8edj is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Sep 2022 05:48:51 GMT

New page: '''Unreleased structure''' The entry 8edj is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8edj is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]