OCA at 07:26, 3 November 2022

OCA — Thu, 03 Nov 2022 07:26:25 GMT

←Older revision		Revision as of 07:26, 3 November 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 8efu is ~~ON HOLD until Paper Publication~~	+	==a22L prion fibril==
-		+	<StructureSection load='8efu' size='340' side='right'caption='[[8efu]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8efu]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efu OCA], [https://pdbe.org/8efu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efu RCSB], [https://www.ebi.ac.uk/pdbsum/8efu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Caughey B]]
		+	[[Category: Hoyt F]]

OCA at 17:11, 19 October 2022

OCA — Wed, 19 Oct 2022 17:11:55 GMT

←Older revision		Revision as of 17:11, 19 October 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8efu is ON HOLD	+	The entry 8efu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8efu" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2022 06:35:37 GMT

Protected "8efu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 21 September 2022

OCA: New page: '''Unreleased structure''' The entry 8efu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 21 Sep 2022 06:35:36 GMT

New page: '''Unreleased structure''' The entry 8efu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8efu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8efu - Revision history

OCA at 07:26, 3 November 2022

OCA at 17:11, 19 October 2022

OCA: Protected "8efu" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8efu is ON HOLD Authors: Description: Category: Unreleased Structures