OCA at 06:13, 19 July 2023

OCA — Wed, 19 Jul 2023 06:13:02 GMT

←Older revision		Revision as of 06:13, 19 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8elj is ~~ON HOLD until Paper Publication~~	+	==SARS-CoV-2 spike glycoprotein in complex with the ICO-hu23 neutralizing antibody Fab fragment==
-		+	<StructureSection load='8elj' size='340' side='right'caption='[[8elj]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8elj]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ELJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ELJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8elj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8elj OCA], [https://pdbe.org/8elj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8elj RCSB], [https://www.ebi.ac.uk/pdbsum/8elj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8elj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Ernst OP]]
		+	[[Category: Kim K]]
		+	[[Category: Kuo A]]
		+	[[Category: Morizumi T]]
		+	[[Category: Yee AW]]

OCA: Protected "8elj" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 19:36:37 GMT

Protected "8elj" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:36, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8elj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jun 2023 19:36:36 GMT

New page: '''Unreleased structure''' The entry 8elj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8elj is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8elj - Revision history

OCA at 06:13, 19 July 2023

OCA: Protected "8elj" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8elj is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures