8ep7 - Revision history

8ep7 - Revision history http://52.214.119.220/wiki/index.php?title=8ep7&action=history Revision history for this page on the wiki en MediaWiki 1.11.2 Sun, 12 Apr 2026 22:46:38 GMT OCA at 10:22, 25 October 2023 http://52.214.119.220/wiki/index.php?title=8ep7&diff=3927653&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 10:22, 25 October 2023</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[8ep7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._'Ames_Ancestor' Bacillus anthracis str. 'Ames Ancestor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP7 FirstGlance]. <br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[8ep7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._'Ames_Ancestor' Bacillus anthracis str. 'Ames Ancestor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP7 FirstGlance]. <br></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></td></tr><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep7 OCA], [https://pdbe.org/8ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep7 ProSAT]</span></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep7 OCA], [https://pdbe.org/8ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep7 ProSAT]</span></td></tr></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[https://www.uniprot.org/uniprot/ILVC2_BACAN ILVC2_BACAN] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[https://www.uniprot.org/uniprot/ILVC2_BACAN ILVC2_BACAN] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==See Also==</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr> </table> Wed, 25 Oct 2023 10:22:53 GMT OCA http://52.214.119.220/wiki/index.php/Talk:8ep7 OCA: Protected "8ep7" [edit=sysop:move=sysop] http://52.214.119.220/wiki/index.php?title=8ep7&diff=3646770&oldid=prev <p>Protected "<a href="/wiki/index.php/8ep7" title="8ep7">8ep7</a>" [edit=sysop:move=sysop]</p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:27, 19 October 2022</td> </tr> </table> Wed, 19 Oct 2022 19:27:34 GMT OCA http://52.214.119.220/wiki/index.php/Talk:8ep7 OCA: New page: ==Crystal Structure of the Ketol-acid Reductoisomerase from Bacillus anthracis in complex with NADP== <StructureSection load='8ep7' size='340' side='right'caption='8ep7, [[Resolution|... http://52.214.119.220/wiki/index.php?title=8ep7&diff=3646768&oldid=prev <p>New page: ==Crystal Structure of the Ketol-acid Reductoisomerase from Bacillus anthracis in complex with NADP== <StructureSection load='8ep7' size='340' side='right'caption='<a href="/wiki/index.php/8ep7" title="8ep7">8ep7</a>, [[Resolution|...</p> <p><b>New page</b></p><div><br /> ==Crystal Structure of the Ketol-acid Reductoisomerase from Bacillus anthracis in complex with NADP==<br /> <StructureSection load='8ep7' size='340' side='right'caption='[[8ep7]], [[Resolution|resolution]] 2.20&Aring;' scene=''><br /> == Structural highlights ==<br /> <table><tr><td colspan='2'>[[8ep7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._'Ames_Ancestor' Bacillus anthracis str. 'Ames Ancestor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP7 FirstGlance]. <br><br /> </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr><br /> <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep7 OCA], [https://pdbe.org/8ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep7 ProSAT]</span></td></tr><br /> </table><br /> == Function ==<br /> [https://www.uniprot.org/uniprot/ILVC2_BACAN ILVC2_BACAN] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]<br /> __TOC__<br /> </StructureSection><br /> [[Category: Bacillus anthracis str. 'Ames Ancestor']]<br /> [[Category: Large Structures]]<br /> [[Category: Gu M]]<br /> [[Category: Joachimiak A]]<br /> [[Category: Kim Y]]<br /> [[Category: Maltseva N]]<br /> [[Category: Osipiuk J]]</div> Wed, 19 Oct 2022 19:27:33 GMT OCA http://52.214.119.220/wiki/index.php/Talk:8ep7