OCA at 14:04, 18 October 2023

OCA — Wed, 18 Oct 2023 14:04:59 GMT

←Older revision		Revision as of 14:04, 18 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8erb is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Fub7 in complex with vinylglycine ketimine==
-		+	<StructureSection load='8erb' size='340' side='right'caption='[[8erb]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~: ~~Hai~~, Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8erb]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_fujikuroi Fusarium fujikuroi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ERB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ERB FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~Fub7 in complex~~ with ~~vinylglycine ketimine~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WBJ:(2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic+acid'>WBJ</scene></td></tr>
-	[[Category: Hai, Y]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8erb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8erb OCA], [https://pdbe.org/8erb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8erb RCSB], [https://www.ebi.ac.uk/pdbsum/8erb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8erb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FUB7_GIBF5 FUB7_GIBF5] Sulfhydrylase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:26662839). L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (PubMed:26662839). The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (PubMed:26662839). FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (PubMed:26662839). Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the O-acetylhomoserine FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (PubMed:26662839). Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (PubMed:26662839).<ref>PMID:26662839</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fusarium fujikuroi]]
		+	[[Category: Large Structures]]
		+	[[Category: Hai Y]]

OCA: Protected "8erb" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 17:28:55 GMT

Protected "8erb" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:28, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8erb is ON HOLD until Paper Publication Authors: Hai, Y. Description: Crystal structure of Fub7 in complex with vinylglycine ketimine [[Category: U...

OCA — Wed, 19 Oct 2022 17:28:52 GMT

New page: '''Unreleased structure''' The entry 8erb is ON HOLD until Paper Publication Authors: Hai, Y. Description: Crystal structure of Fub7 in complex with vinylglycine ketimine [[Category: U...

New page

'''Unreleased structure'''

The entry 8erb is ON HOLD until Paper Publication

Authors: Hai, Y.

Description: Crystal structure of Fub7 in complex with vinylglycine ketimine
[[Category: Unreleased Structures]]
[[Category: Hai, Y]]

8erb - Revision history

OCA at 14:04, 18 October 2023

OCA: Protected "8erb" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8erb is ON HOLD until Paper Publication Authors: Hai, Y. Description: Crystal structure of Fub7 in complex with vinylglycine ketimine [[Category: U...