8ese - Revision history

OCA at 10:23, 25 October 2023

OCA — Wed, 25 Oct 2023 10:23:34 GMT

←Older revision		Revision as of 10:23, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[8ese]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESE FirstGlance]. <br>		<table><tr><td colspan='2'>[[8ese]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ese FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ese OCA], [https://pdbe.org/8ese PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ese RCSB], [https://www.ebi.ac.uk/pdbsum/8ese PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ese ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ese FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ese OCA], [https://pdbe.org/8ese PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ese RCSB], [https://www.ebi.ac.uk/pdbsum/8ese PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ese ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:04, 25 May 2023

OCA — Thu, 25 May 2023 04:04:54 GMT

←Older revision		Revision as of 04:04, 25 May 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8ese is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human Vps29 bound to a peptide from Vps35L==
		+	<StructureSection load='8ese' size='340' side='right'caption='[[8ese]], [[Resolution\|resolution]] 1.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8ese]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ese FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ese OCA], [https://pdbe.org/8ese PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ese RCSB], [https://www.ebi.ac.uk/pdbsum/8ese PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ese ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B3KT69_HUMAN B3KT69_HUMAN]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the coiled-coil domain-containing (CCDC) proteins CCDC22 and CCDC93. Combining X-ray crystallography, electron cryomicroscopy, and in silico predictions, we have assembled a complete structural model of Commander. Retriever is distantly related to the endosomal Retromer complex but has unique features preventing the shared VPS29 subunit from interacting with Retromer-associated factors. The COMMD proteins form a distinctive hetero-decameric ring stabilized by extensive interactions with CCDC22 and CCDC93. These adopt a coiled-coil structure that connects the CCC and Retriever assemblies and recruits a 16th subunit, DENND10, to form the complete Commander complex. The structure allows mapping of disease-causing mutations and reveals the molecular features required for the function of this evolutionarily conserved trafficking machinery.

-	~~Authors:~~ Healy, M~~.D.~~, Collins, B.M.	+	Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.,Healy MD, McNally KE, Butkovic R, Chilton M, Kato K, Sacharz J, McConville C, Moody ERR, Shaw S, Planelles-Herrero VJ, Yadav SKN, Ross J, Borucu U, Palmer CS, Chen KE, Croll TI, Hall RJ, Caruana NJ, Ghai R, Nguyen THD, Heesom KJ, Saitoh S, Berger I, Schaffitzel C, Williams TA, Stroud DA, Derivery E, Collins BM, Cullen PJ Cell. 2023 May 11;186(10):2219-2237.e29. doi: 10.1016/j.cell.2023.04.003. PMID:37172566<ref>PMID:37172566</ref>

-	~~Description: Crystal structure of human Vps29 bound to~~ a ~~peptide from Vps35L~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Collins~~, B.M~~]]	+	<div class="pdbe-citations 8ese" style="background-color:#fffaf0;"></div>
-	[[Category: Healy~~, M.D~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Collins BM]]
		+	[[Category: Healy MD]]

OCA at 18:08, 16 November 2022

OCA — Wed, 16 Nov 2022 18:08:04 GMT

←Older revision		Revision as of 18:08, 16 November 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ese is ON HOLD	+	The entry 8ese is ON HOLD until Paper Publication

	Authors: Healy, M.D., Collins, B.M.		Authors: Healy, M.D., Collins, B.M.

OCA: Protected "8ese" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 17:32:24 GMT

Protected "8ese" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:32, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8ese is ON HOLD Authors: Healy, M.D., Collins, B.M. Description: Crystal structure of human Vps29 bound to a peptide from Vps35L [[Category: Unrele...

OCA — Wed, 19 Oct 2022 17:32:22 GMT

New page: '''Unreleased structure''' The entry 8ese is ON HOLD Authors: Healy, M.D., Collins, B.M. Description: Crystal structure of human Vps29 bound to a peptide from Vps35L [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 8ese is ON HOLD

Authors: Healy, M.D., Collins, B.M.

Description: Crystal structure of human Vps29 bound to a peptide from Vps35L
[[Category: Unreleased Structures]]
[[Category: Collins, B.M]]
[[Category: Healy, M.D]]