OCA at 07:04, 25 October 2023

OCA — Wed, 25 Oct 2023 07:04:16 GMT

←Older revision		Revision as of 07:04, 25 October 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8esf is ~~ON HOLD~~	+	==Crystal structure of human Nischarin PX and LRR domains with engineered mutations==
-		+	<StructureSection load='8esf' size='340' side='right'caption='[[8esf]], [[Resolution\|resolution]] 2.56Å' scene=''>
-	~~Authors~~: ~~Eldershaw~~, D.E., ~~Collins~~, B.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8esf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ESF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ESF FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~human Nischarin PX~~ and ~~LRR domains~~ with ~~engineered mutations~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.56Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
-	[[Category: ~~Eldershaw, D.E~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8esf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8esf OCA], [https://pdbe.org/8esf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8esf RCSB], [https://www.ebi.ac.uk/pdbsum/8esf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8esf ProSAT]</span></td></tr>
-	[[Category: Collins~~, B.M~~]]	+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NISCH_HUMAN NISCH_HUMAN] Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.<ref>PMID:10882231</ref> <ref>PMID:12868002</ref> <ref>PMID:15028619</ref> <ref>PMID:15028621</ref> <ref>PMID:15475348</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Collins BM]]
		+	[[Category: Eldershaw DE]]

OCA: Protected "8esf" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2022 17:32:29 GMT

Protected "8esf" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:32, 19 October 2022

OCA: New page: '''Unreleased structure''' The entry 8esf is ON HOLD Authors: Eldershaw, D.E., Collins, B.M. Description: Crystal structure of human Nischarin PX and LRR domains with engineered mutati...

OCA — Wed, 19 Oct 2022 17:32:27 GMT

New page: '''Unreleased structure''' The entry 8esf is ON HOLD Authors: Eldershaw, D.E., Collins, B.M. Description: Crystal structure of human Nischarin PX and LRR domains with engineered mutati...

New page

'''Unreleased structure'''

The entry 8esf is ON HOLD

Authors: Eldershaw, D.E., Collins, B.M.

Description: Crystal structure of human Nischarin PX and LRR domains with engineered mutations
[[Category: Unreleased Structures]]
[[Category: Eldershaw, D.E]]
[[Category: Collins, B.M]]

8esf - Revision history

OCA at 07:04, 25 October 2023

OCA: Protected "8esf" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8esf is ON HOLD Authors: Eldershaw, D.E., Collins, B.M. Description: Crystal structure of human Nischarin PX and LRR domains with engineered mutati...